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Combination of Poly L-Lactic Acid Nanofiber Scaffold With Omentum Graft for Bone Healing in Experimental Defect in Tibia of Rabbits; [Combinacao De Poli L-Acido Lactico Nanofbras Com Enxerto De Omento Para Reparo Osseo Em Defeito Experimental Em Tibia De Coelhos] Publisher Pubmed



Sotoudeh A1 ; Jahanshahi G2 ; Jahanshahi A3 ; Takhtfooladi MA3 ; Shabani I4 ; Soleimani M5
Authors
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Authors Affiliations
  1. 1. Department of Veterinary Science, Kahnooj Branch, Islamic Azad University, Kerman, Iran
  2. 2. Esfahan University of Medical Science, School of Dentistry, Department of Oral Pathology, Esfahan, Iran
  3. 3. Department of Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
  4. 4. Nanotechnology and Tissue Engineering Department, Stem Cell Technology Research Center, Tehran, Iran
  5. 5. Hematology Department, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran

Source: Acta Cirurgica Brasileira Published:2012


Abstract

PURPOSE: To investigate the osteoconductive properties and biological performance of Poly L-lactic acid (PLLA) with omentum in bone defects. METHODS: PLLA nanofiber scaffolds were prepared via electrospinning technique. Forty four New Zealand white female rabbits randomly divided into three groups of 18 rabbits each. Created defects in right tibias were filled in group I with omentum, in group II with PLLA nanofiber scaffold and in group III with combination of the omentum and PLLA. The same defects were created in left tibia of all groups but did not receive any treatment (control group). Histological and histomorphometric evaluations were performed at two, four and six weeks after the implantation. RESULTS: Histological changes on all groups along with the time course were scored and statistical analysis showed that the average scores in group III were significantly higher than the other groups. CONCLUSION: Histomorphometric analysis of bone healing was shown to be significantly improved by the combined PLLA with omentum compared with the other groups, suggesting this biomaterial promote the healing of cortical bone, presumably by acting as anosteoconductive scaffold.
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