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Modified Alternate-Day Fasting Vs. Calorie Restriction in the Treatment of Patients With Metabolic Syndrome: A Randomized Clinical Trial Publisher Pubmed



Parvaresh A1 ; Razavi R1 ; Abbasi B2 ; Yaghoobloo K1 ; Hassanzadeh A3 ; Mohammadifard N4 ; Safavi SM1 ; Hadi A5 ; Clark CCT6
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Assistant Professor of Nutrition. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of health, Isfahan University of Medical Science, Isfahan, Iran
  4. 4. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran
  5. 5. Halal Research Center of IRI, FDA, Tehran, Iran
  6. 6. Faculty Research Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, United Kingdom

Source: Complementary Therapies in Medicine Published:2019


Abstract

Objective: : The aim of present study was to compare the effect of calorie restriction and modified alternate-day fasting diet on treatment of adults with metabolic syndrome. Design: : This randomized clinical trial was conducted on 70 participants diagnosed with metabolic syndrome. Setting: : Patients were randomly allocated into 2 groups to follow either calorie restriction or a modified alternate-day fasting diet for 8 weeks. Diets was prescribed by dietitians and specialized for each participant. Anthropometric parameters, blood pressure, fasting plasma glucose, fasting insulin, HOMA-IR and lipid profile were measured at baseline and after trial conclusion. Results: : 69, out of 70, participants completed the study and were included in the final analysis. The results showed that, compared with calorie restriction, following the modified alternate-day fasting diet significantly reduced body weight (P = 0.003), waist circumference (P = 0.026), systolic blood pressure (P = 0.029) and fasting plasma glucose (P = 0.009). However, no significant difference was observed between the 2 groups in triglyceride (P = 0.614), total cholesterol (P = 0.759), LDL-C (P = 0.289), HDL-C (P = 0.909), diastolic blood pressure (P = 0.262), HOMA- IR (P = 0.425) and fasting insulin concentrations (P = 0.496). In addition, the participants did not report any complaint due to difficulties with diet adherence when following calorie restriction or modified alternate-day fasting diet. Conclusions: : the present study suggests that modified alternate-day fasting diet may be a more effective option in managing body weight, waist circumference, systolic blood pressure, and fasting plasma glucose, compared with common calorie restriction. Further studies are needed to confirm the veracity of our results. © 2019 Elsevier Ltd
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