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The Alternate-Day Fasting Diet Is a More Effective Approach Than a Calorie Restriction Diet on Weight Loss and Hs-Crp Levels Publisher Pubmed



Razavi R1 ; Parvaresh A1 ; Abbasi B2 ; Yaghoobloo K1 ; Hassanzadeh A3 ; Mohammadifard N4 ; Clark CCT5 ; Morteza Safavi S1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Science, Isfahan, Iran
  4. 4. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Science, Isfahan, Iran
  5. 5. Faculty Research Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, United Kingdom

Source: International Journal for Vitamin and Nutrition Research Published:2021


Abstract

Background and Objective: The aim of present study was to compare, and determine, the effects of a modified alternate-day fasting diet vs. calorie restriction on inflammatory indices and coagulation factors. Methods: This was a randomized clinical trial consisting of 80 metabolic syndrome patients, who were enrolled and randomly dichotomized into a modified alternate-day fasting diet or calorie restriction group for 4 months. We measured weight, body mass index (BMI), waist circumstance (WC), waist-hip-ratio (WHR) and fat mass as primary outcomes and assessed high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α) and coagulation factors levels as secondary outcomes before and after intervention. Results: Compared to the calorie restriction diet, following a modified alternate-day fasting diet led to a greater reduction in body weight (kg) (–6.43 ± 4.34 vs –4.11 ± 4.27; P = 0.02), BMI (kg/m2) (–3.19 ± 2.90 vs –1.43 ± 2.72; P = 0.01), fat mass (kg) (–4.88 ± 2.09 vs –3.72 ± 2.43; P = 0.03), WC (cm) (–5.57 ± 5.64 vs –2.32 ± 5.95; P = 0.01) and WHR (–0.05 ± 0.06 vs –0.02 ± 0.07; P = 0.04). Furthermore, a greater change was found in hs-CRP levels (mg/L) (–2.06 ± 1.18 vs –0.97 ± 0.82; P = 0.03), prothrombin time (s) (1.41 ± 2.34 vs –0.41 ± 2.17; P < 0.001), activated partial thromboplastin time (s) (0.26 ± 3.70 vs –1.78 ± 3.56; P = 0.04) in modified alternate-day fasting diet when compared to calorie restriction diet. However, there was no difference in TNF-α or IL-6 and fibrinogen between groups (P > 0.05). Conclusions: These findings suggest that a modified alternate-day fasting diet can be a beneficial alternative for the management of body weight, fat mass and WC as well as hs-CRP and coagulation factors levels among metabolic syndrome patients. © 2021 Hogrefe Verlag GmbH & Co. KG. All rights reserved.
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