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Carbon Dots With Tissue Engineering and Regenerative Medicine Applications Publisher



Farshidfar N1 ; Fooladi S2 ; Nematollahi MH3, 4 ; Iravani S5
Authors
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Authors Affiliations
  1. 1. Orthodontic Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Applied Cellular and Molecular Research Center, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Department of Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  5. 5. Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran

Source: RSC Advances Published:2023


Abstract

Carbon dots (CDs) with unique physicochemical features such as exceptional biocompatibility, low cost, eco-friendliness, abundant functional groups (e.g., amino, hydroxyl, and carboxyl), high stability, and electron mobility have been broadly investigated in nano- and biomedicine. In addition, the controlled architecture, tunable fluorescence emission/excitation, light-emitting potential, high photostability, high water solubility, low cytotoxicity, and biodegradability make these carbon-based nanomaterials suitable for tissue engineering and regenerative medicine (TE-RM) purposes. However, there are still limited pre- and clinical assessments, because of some important challenges such as the scaffold inconsistency and non-biodegradability in addition to the lack of non-invasive methods to monitor tissue regeneration after implantation. In addition, the eco-friendly synthesis of CDs exhibited some important advantages such as environmentally friendly properties, low cost, and simplicity compared to the conventional synthesis techniques. Several CD-based nanosystems have been designed with stable photoluminescence, high-resolution imaging of live cells, excellent biocompatibility, fluorescence properties, and low cytotoxicity, which make them promising candidates for TE-RM purposes. Combining attractive fluorescence properties, CDs have shown great potential for cell culture and other biomedical applications. Herein, recent advancements and new discoveries of CDs in TE-RM are considered, focusing on challenges and future perspectives. © 2023 The Royal Society of Chemistry.
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