Imaging Techniques: New Avenues in Cancer Gene and Cell Therapy Publisher Pubmed



Saadatpour Z¹ ; Rezaei A² ; Ebrahimnejad H³ ; Baghaei B⁴ ; Bjorklund G⁵ ; Chartrand M⁶ ; Sahebkar A⁷ ; Morovati H⁸ ; Mirzaei HR⁹ ; Mirzaei H¹⁰ Show Affiliations
Source: Cancer Gene Therapy Published:2017

Abstract

Cancer is one of the world's most concerning health problems and poses many challenges in the range of approaches associated with the treatment of cancer. Current understanding of this disease brings to the fore a number of novel therapies that can be useful in the treatment of cancer. Among them, gene and cell therapies have emerged as novel and effective approaches. One of the most important challenges for cancer gene and cell therapies is correct monitoring of the modified genes and cells. In fact, visual tracking of therapeutic cells, immune cells, stem cells and genetic vectors that contain therapeutic genes and the various drugs is important in cancer therapy. Similarly, molecular imaging, such as nanosystems, fluorescence, bioluminescence, positron emission tomography, single photon-emission computed tomography and magnetic resonance imaging, have also been found to be powerful tools in monitoring cancer patients who have received therapeutic cell and gene therapies or drug therapies. In this review, we focus on these therapies and their molecular imaging techniques in treating and monitoring the progress of the therapies on various types of cancer.