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Evaluation of the Effects of Β-Tricalcium Phosphate on Physical, Mechanical and Biological Properties of Poly (3-Hydroxybutyrate)/Chitosan Electrospun Scaffold for Cartilage Tissue Engineering Applications Publisher



Keikhaei S1 ; Mohammadalizadeh Z2 ; Karbasi S2 ; Salimi A3
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, Iran
  2. 2. Department of Biomaterials and Tissue Engineering, School of Advance Technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Applied Microbiology Research Center, Baqiyatallah University Medical of Sciences, Tehran, Iran

Source: Materials Technology Published:2019


Abstract

Scaffold designing for cartilage tissue engineering requires suitable physico-mechanical and biological properties. This research was carried out to study the effects of β-tricalcium phosphate nanoparticles (β-TCP) on Poly (3-hydroxybutyrate) (PHB)-chitosan (Cs) electrospun scaffold. Results showed that the addition of different amounts of β-TCP increased fibre diameter, porosity, hydrophilicity and tensile strength in the proper condition. An increase in the degradation rate was observed by an increase in the amount of β-TCP. The biological behaviour of the PHB-Cs/7.5%wt β-TCP electrospun nanocomposite scaffold was investigated through the formation of apatite-like granules and proper attachment and proliferation of chondrocytes on the surface of scaffolds. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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