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Evaluation of the Effects of Β-Tricalcium Phosphate on Physical, Mechanical and Biological Properties of Poly (3-Hydroxybutyrate)/Chitosan Electrospun Scaffold for Cartilage Tissue Engineering Applications Publisher

Summary: A study found adding nanoparticles to scaffolds boosts cartilage repair, promising better joint healing. #JointHealth #TissueEngineering

Keikhaei S1 ; Mohammadalizadeh Z2 ; Karbasi S2 ; Salimi A3
Authors

Source: Materials Technology Published:2019


Abstract

Scaffold designing for cartilage tissue engineering requires suitable physico-mechanical and biological properties. This research was carried out to study the effects of β-tricalcium phosphate nanoparticles (β-TCP) on Poly (3-hydroxybutyrate) (PHB)-chitosan (Cs) electrospun scaffold. Results showed that the addition of different amounts of β-TCP increased fibre diameter, porosity, hydrophilicity and tensile strength in the proper condition. An increase in the degradation rate was observed by an increase in the amount of β-TCP. The biological behaviour of the PHB-Cs/7.5%wt β-TCP electrospun nanocomposite scaffold was investigated through the formation of apatite-like granules and proper attachment and proliferation of chondrocytes on the surface of scaffolds. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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