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Evaluation of the Effects of Chitosan/Multiwalled Carbon Nanotubes Composite on Physical, Mechanical and Biological Properties of Polymethyl Methacrylate-Based Bone Cements Publisher



Eil Bakhtiari SS1 ; Karbasi S2 ; Hassanzadeh Tabrizi SA1 ; Ebrahimikahrizsangi R1 ; Salehi H3
Authors
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Authors Affiliations
  1. 1. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  2. 2. Biomaterials and Tissue Engineering Department, School of Advanced technology in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Materials Technology Published:2020


Abstract

Because of some undesirable properties of polymethyl methacrylate(PMMA) bone cement, it is necessary to adopt a new strategy to improve its function. In this study, after preparing of chitosan (CS) powder and CS/multiwalled carbon nanotubes (MWCNTs) composite powder, they were added to the PMMA bone cement in different percentages with homogeneous distribution. The results showed that by adding CS/MWCNTs to the PMMA, injectability and setting time were increased and maximum temperature and contact angle were decreased, significantly. Mechanical tests showed that by adding 25 wt. % of CS/MWCNTs to the PMMA, the compressive and bending strength were increased, significantly. According to the results obtained from the bioactivity and cellular activity test, by adding 25 wt. % of CS/MWCNTs to the PMMA, apatite like deposition and extra cellular matrix formation were increased, significantly. Accordingly, 25 wt. % PMMA-CS/MWCNTs composite can create a new approach to improve commercial bone cements. © 2019 Informa UK Limited, trading as Taylor & Francis Group.
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