Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Gastric Floating Matrix Tablets of Metformin Hcl: Design and Optimization Using Combination of Polymers



Bahrinajafi R1 ; Tavakoli N1 ; Taymouri S1 ; Shokatjalil S2
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Novel Drug Delivery Systems Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Science, Isfahan, Iran
  2. 2. Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Science, Isfahan, Iran

Source: Journal of Reports in Pharmaceutical Sciences Published:2016

Abstract

The objective of this study was to develop a floating drug delivery system (FDDS) from metformin hydrochloride to enhance gastro residence time (GRT), with floating properties which remain in the stomach more than gastric empting time (GET). Eight batches were prepared using hydrophilic polymers as release-retarding, and sodium bicarbonate as a gas former by direct compression technique. The effects of effervescent agent (sodium bicarbonate) and a binary combination of hydroxypropyl methylcellulose (HPMC) K4M with polyvinylpyrrolidone (PVP) or carbopol934 on floating properties and drug release profile were investigated. Drug release study was evaluated for 12 hours using USP paddle-type dissolution apparatus using 0.1N HCl in 37±0.5˚C as dissolution medium. The swelling index, floating behavior and kinetic parameter were found to be regulated by polymers and CO2 generating agent content. The results of powder ingredients and compressed tablets showed acceptable physicochemical properties. It was found that polymer content affected in the release rate constant and diffusion exponent. Statistical analyses of formulations data exhibited that F7 formulation was promising systems revealing excellent floating properties and sustained drug release characteristics. The MDT and DE12h of F7 formulation were calculated to be 5.26h and 49.88%, respectively. Drug release profile of F7 formulation followed non-Fickian diffusion with Hixson-crowell model. © 2016 by Kermanshah University of Medical Sciences.
Related Docs
View other Related Docs
1. Preparation and in Vitro-In Vivo Evaluation of Acyclovir Floating Tablets, Research in Pharmaceutical Sciences (2017)
2. Formulation and in Vitro Characterization of Ciprofloxacin Floating and Bioadhesive Extended-Release Tablets, Drug Delivery (2006)
3. Development of a Prolonged-Release Gastroretentive Tablet Formulation of Ciprofloxacin Hydrochloride: Pharmacokinetic Characterization in Healthy Human Volunteers, International Journal of Pharmaceutics (2011)
4. Formulation and Pharmaceutical Evaluation of Ferric-Maltol Floating Table, Journal of Reports in Pharmaceutical Sciences (2014)
5. Preparation and Pharmaceutical Evaluation of Ferrous Sulfate and Ascorbic Acid Floating Matrix Tablet for Prevention of Anemia, Journal of Reports in Pharmaceutical Sciences (2012)
6. Preparation and Evaluation of a New Salbutamol Fast-Dissolving Oral Film for Asthma Treatment, Journal of Isfahan Medical School (2013)
7. Preparation and Characterization of a Sustained Release Buccoadhesive System for Delivery of Terbutaline Sulfate, Research in Pharmaceutical Sciences (2013)
8. Dissolution Enhancement of Glibenclamide by Solid Dispersion: Solvent Evaporation Versus a Supercritical Fluid-Based Solvent -Antisolvent Technique, Research in Pharmaceutical Sciences (2014)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (17)
Somayeh Taymouri (4)
Other Related Docs
9. Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol Through Rat Skin, Journal of Nanomaterials (2013)
10. Preparation and Characterization of a Hydroxypropyl Methylcellulose Based Wafer for Simultaneous Delivery of Phenytoin and Insulin As Wound Dressing Material, Pharmaceutical Development and Technology (2022)
11. Preparation and Pharmaceutical Evaluation of Glibenclamide Slow Release Mucoadhesive Buccal Film, Research in Pharmaceutical Sciences (2014)
12. Use of Enteric Polymers for Production of Microspheres by Extrusion-Spheronization, Pharmaceutica Acta Helvetiae (1997)
13. Characterization of Drug Release and Diffusion Mechanism Through Hydroxyethylmethacrylate/Methacrylic Acid Ph-Sensitive Hydrogel, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2004)
14. Development and Evaluation of Sustained-Release Propranolol Wax Microspheres, Journal of Microencapsulation (2001)
15. Preparation and Physicochemical Evaluation of Oral Disintegrated Tablet Containing Dicyclomine Hydrochloride, Journal of Reports in Pharmaceutical Sciences (2018)
16. Enhancement of Dissolution Rate of Fenofibrate by Spray Drying Technique: Comparison of Eudragit E-100, Solutol® Hs15 and Hydroxypropyl Cellulose As Carriers, Farmacia (2015)
17. Development and Validation of a Simple Hplc Method for Simultaneous in Vitro Determination of Amoxicillin and Metronidazole at Single Wavelength, Journal of Pharmaceutical and Biomedical Analysis (2007)
18. Use of Natural Gums and Cellulose Derivatives in Production of Sustained Release Metoprolol Tablets, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
19. Development and Evaluation of a Monolithic Floating Drug Delivery System for Acyclovir, Chemical and Pharmaceutical Bulletin (2012)
20. Enhancement of Solubility and Antidiabetic Effects of Repaglinide Using Spray Drying Technique in Stz-Induced Diabetic Rats, Pharmaceutical Development and Technology (2017)
21. Influence of Different Solid-Dispersion Techniques Upon the Release of Dimenhydrinate From Chewing-Gum Formulations, Scientia Pharmaceutica (2002)
22. Dual Thermo- and Ph-Responsive Poly(N-Isopropylacrylamide-Co-(2-Dimethylamino) Ethyl Methacrylate)-G-Peg Nanoparticle System and Its Potential in Controlled Drug Release, Polymer Bulletin (2020)
23. Development and Characterization of Floating Microballoons for Oral Delivery of Cinnarizine by a Factorial Design, Journal of Microencapsulation (2007)
24. Preparation and Evaluation of Theophylline Sustained Release Microcapsules Using Coacervation, Journal of Dispersion Science and Technology (2012)
25. Use of Hydrophilic Natural Gums in Formulation of Sustained-Release Matrix Tablets of Tramadol Hydrochloride, AAPS PharmSciTech (2006)
26. Development and Characterization of Buccoadhesive Nifedipine Tablets, European Journal of Pharmaceutics and Biopharmaceutics (2002)
27. Preparation and in Vitro Evaluation of Sustained-Release Matrix Tablets of Flutamide Using Synthetic and Naturally Occurring Polymers, Iranian Journal of Pharmaceutical Research (2008)
28. Influence of Β - Cyclodextrin Complexation on Lovastatin Release From Osmotic Pump Tablets (Opt), Daru (2007)
29. Formulation, Characterization and Physicochemical Evaluation of Ranitidine Effervescent Tablets, Advanced Pharmaceutical Bulletin (2013)
30. Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System, Drug Development and Industrial Pharmacy (2007)
31. Preparation and Characterization of Metoprolol Controlled-Release Solid Dispersions, Drug Delivery (2006)
32. Simvastatin Nanosuspensions Prepared Using a Combination of Ph-Sensitive and Timed-Release Approaches for Potential Treatment of Colorectal Cancer, Pharmaceutical Development and Technology (2021)