Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Use of Hydrophilic Natural Gums in Formulation of Sustained-Release Matrix Tablets of Tramadol Hydrochloride Publisher Pubmed



Varshosaz J1 ; Tavakoli N1 ; Kheirolahi F1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: AAPS PharmSciTech Published:2006


Abstract

The objective of this work was to develop matrix sustained-release tablets of highly water-soluble tramadol HCl using natural gums (xanthan [X gum] and guar [G gum]) as cost-effective, nontoxic, easily available, and suitable hydrophilic matrix systems compared with the extensively investigated hydrophilic matrices (ie, hydroxypropyl methylcellulose [HPMC]/carboxymethyl cellulose [CMC] with respect to in vitro drug release rate) and hydration rate of the polymers. Matrix tablets of tramadol (dose 100 mg) were produced by direct compression method. Different ratios of 100:0, 80:20, 60:40,20:80, 0:100 of G gum (or X):BPMC, X gum:G gum, and triple mixture of these polymers (G gum, X gum, HPMC) were applied. After evaluation of physical characteristics of tablets, the dissolution test was performed in the phosphate buffer media (pH 7.4) up to 8 hours. Tablets with only X had the highest mean dissolution time (MDT), the least dissolution efficiency (DE8%), and released the drug following a zero-order model via swelling, diffusion, and erosion mechanisms. Guar gum alone could not efficiently control the drug release, while X and all combinations of natural gums with HPMC could retard tramadol HCl release. However, according to the similarity factor (f2), pure HPMC and H8G2 were the most similar formulations to Topalgic-LP as the reference standard.
Related Docs
View other Related Docs
1. Use of Natural Gums and Cellulose Derivatives in Production of Sustained Release Metoprolol Tablets, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
2. Preparation and in Vitro Evaluation of Sustained-Release Matrix Tablets of Flutamide Using Synthetic and Naturally Occurring Polymers, Iranian Journal of Pharmaceutical Research (2008)
3. Applying the Taguchi Design for Optimized Formulation of Sustained Release Gliclazide Chitosan Beads: An in Vitro/In Vivo Study, AAPS PharmSciTech (2009)
4. Dissolution Enhancement of Glibenclamide by Solid Dispersion: Solvent Evaporation Versus a Supercritical Fluid-Based Solvent -Antisolvent Technique, Research in Pharmaceutical Sciences (2014)
5. Design, Formulation, and Physicochemical Evaluation of Montelukast Orally Disintegrating Tablet, International Journal of Preventive Medicine (2016)
6. Development and Physical Characterization of a Periodontal Bioadhesive Gel of Metronidazole, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2002)
7. Development of Lecithin Nanoemulsion Based Organogels for Permeation Enhancement of Metoprolol Through Rat Skin, Journal of Nanomaterials (2013)
8. Evaluation of Trigonella Foenum-Graecum Seeds Gum As a Novel Tablet Binder, International Journal of Pharmacy and Pharmaceutical Sciences (2012)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (29)
Somayeh Taymouri (5)
Other Related Docs
9. Formulation and Evaluation of Orally Disintegrating Tablet of Ondansetron Using Natural Superdisintegrant, Journal of HerbMed Pharmacology (2015)
10. Preparation and Pharmaceutical Evaluation of Glibenclamide Slow Release Mucoadhesive Buccal Film, Research in Pharmaceutical Sciences (2014)
11. An Injectable Carboxymethyl Chitosan-Methylcellulose-Pluronic Hydrogel for the Encapsulation of Meloxicam Loaded Nanoparticles, International Journal of Biological Macromolecules (2020)
12. Application of Taguchi Method to Investigate the Drug Release Behavior of Poly(Acrylamide-Co-Maleic Acid)/Montmorillonite Nanocomposite Hydrogels, Advances in Polymer Technology (2014)
13. Use of Enteric Polymers for Production of Microspheres by Extrusion-Spheronization, Pharmaceutica Acta Helvetiae (1997)
14. Preparation and Characterization of Solid Dispersions of Celecoxib Obtained by Spray-Drying Ethanolic Suspensions Containing Pvp-K30 or Isomalt, Journal of Drug Delivery Science and Technology (2018)
15. Enhancement of Dissolution Rate of Fenofibrate by Spray Drying Technique: Comparison of Eudragit E-100, Solutol® Hs15 and Hydroxypropyl Cellulose As Carriers, Farmacia (2015)
16. Effects of Concentration, Temperature and Polymer Type on Drug Release From Montmorillonite-Donepezil Nanocomposites, Journal of Isfahan Medical School (2013)
17. Nanocrystalization of Pioglitazone by Precipitation Method, Drug Research (2018)
18. Medicated Chewing Gum, a Novel Drug Delivery System, Journal of Research in Medical Sciences (2015)
19. Effect of High-Pressure Homogenization Treatment and Persian Gum on Rheological, Functional Properties and Release Kinetic of Crocin From Double Emulsions, LWT (2023)
20. Polyelectrolyte Complexes of Chitosan for Production of Sustained Release Tablets of Bupropion Hcl, Farmacia (2015)
21. Development and in Vitro/In Vivo Evaluation of Hpmc/Chitosan Gel Containing Simvastatin Loaded Self-Assembled Nanomicelles As a Potent Wound Healing Agent, Drug Development and Industrial Pharmacy (2018)
22. Enhancement of Solubility and Antidiabetic Effects of Repaglinide Using Spray Drying Technique in Stz-Induced Diabetic Rats, Pharmaceutical Development and Technology (2017)
23. Influence of Different Solid-Dispersion Techniques Upon the Release of Dimenhydrinate From Chewing-Gum Formulations, Scientia Pharmaceutica (2002)
24. Development and Characterization of Floating Microballoons for Oral Delivery of Cinnarizine by a Factorial Design, Journal of Microencapsulation (2007)
25. Gastric Floating Matrix Tablets of Metformin Hcl: Design and Optimization Using Combination of Polymers, Journal of Reports in Pharmaceutical Sciences (2016)
26. Colon-Specific Delivery of Mesalazine Chitosan Microspheres, Journal of Microencapsulation (2006)
27. Biocompatible Nanocomposite Scaffolds Based on Carrageenan Incorporating Hydroxyapatite and Hesperidin Loaded Nanoparticles for Bone Tissue Regeneration, Polymers for Advanced Technologies (2024)
28. Development and Characterization of Buccoadhesive Nifedipine Tablets, European Journal of Pharmaceutics and Biopharmaceutics (2002)
29. Enhancement of Anti-Diabetic Effects of Gliclazide Using Immediate Release Tablets in Streptozotocin-Induced Diabetic and Normal Rats, Farmacia (2013)
30. Gliclazide Microcrystals Prepared by Two Methods of in Situ Micronization: Pharmacokinetic Studies in Diabetic and Normal Rats, AAPS PharmSciTech (2010)
31. Injectable Gellan Gum/Lignocellulose Nanofibrils Hydrogels Enriched With Melatonin Loaded Forsterite Nanoparticles for Cartilage Tissue Engineering: Fabrication, Characterization and Cell Culture Studies, Materials Science and Engineering C (2020)
32. Influence of Β - Cyclodextrin Complexation on Lovastatin Release From Osmotic Pump Tablets (Opt), Daru (2007)
33. Fabrication of Polymeric Nanoparticles of Poly(Ethylene-Co-Vinyl Acetate) Coated With Chitosan for Pulmonary Delivery of Carvedilol, Journal of Applied Polymer Science (2014)
34. Cross-Linked Poly (Vinyl Alcohol) Hydrogel: Study of Swelling and Drug Release Behaviour, Iranian Polymer Journal (English Edition) (2002)
35. A Brief Review of Hydrogels for Drug Delivery for Different Organs of the Body: Synthesis, Categorization, and Organ-Specific Applications, Nanochemistry Research (2024)
36. Formulation of Sustained - Release Lithium Carbonate Matrix Tablets: Influence of Hydrophilic Materials on the Release Rate and in Vitro-In Vivo Evaluation, Journal of Pharmacy and Pharmaceutical Sciences (2004)
37. Gellan Gum–Based Nanocomposite Hydrogels, Application of Gellan Gum as a Biomedical Polymer (2024)
38. Composite Hydrogel-Embedded Sucrose Stearate Niosomes: Unique Curcumin Delivery System, Food and Bioprocess Technology (2022)
39. Colon Specific Delivery of Budesonide Based on Triple Coated Pellets: In Vitro/In Vivo Evaluation, Acta Pharmaceutica (2012)
40. Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System, Drug Development and Industrial Pharmacy (2007)
41. Preparation, Characterization and Optimization of Glipizide Controlled Release Nanoparticles, Research in Pharmaceutical Sciences (2014)
42. Thermal Treating of Acrylic Matrices As a Tool for Controlling Drug Release, Chemical and Pharmaceutical Bulletin (2009)
43. Preparation and Characterization of Metoprolol Controlled-Release Solid Dispersions, Drug Delivery (2006)
44. Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design, Journal of Nanomaterials (2012)
45. Simvastatin Nanosuspensions Prepared Using a Combination of Ph-Sensitive and Timed-Release Approaches for Potential Treatment of Colorectal Cancer, Pharmaceutical Development and Technology (2021)
46. Thermo-Responsive Hydrogels Based on Methylcellulose/Persian Gum Loaded With Taxifolin Enhance Bone Regeneration: An in Vitro/In Vivo Study, Cellulose (2022)
47. Preparation and in Vitro/In Vivo Evaluation of Dextran Matrix Tablets of Budesonide in Experimental Ulcerative Colitis in Rats, Drug Delivery (2011)
48. Double-Walled Microspheres Loaded With Meglumine Antimoniate: Preparation, Characterization and in Vitro Release Study, Drug Development and Industrial Pharmacy (2014)