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Hepatoprotective Effects of Iranian Hypericum Scabrum Essential Oils Against Oxidative Stress Induced by Acetaminophen in Rats Publisher



Dadkhah A1 ; Fatemi F2 ; Farsani ME3 ; Roshanaei K4 ; Alipour M4 ; Aligolzadeh H5
Authors
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Authors Affiliations
  1. 1. Department of Medicine, Faculty of Medicine, Islamic Azad University, Qom Branch, Qom-I.R., Iran
  2. 2. Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran - I.R., Iran
  3. 3. Department of Anatomy Science and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Physiology, Faculty of Science, Islamic Azad University, Qom Branch, Qom - I.R., Iran
  5. 5. Azizi Hospital-Juybar, Mazandaran University of Medical Sciences, Sari - I.R, Iran

Source: Brazilian Archives of Biology and Technology Published:2014


Abstract

This studied examined the protective role of Hypericum scabrum oils (100 and 200 mg/kg b.w, i.p) on acetaminophen-induced liver damages in the rat. The hepatic oxidative/antioxidant parameters such as lipid peroxidation (LP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and ferric reducing ability of plasma (FRAP) were measured 2, 4, 8, 16 and 24h after the treatments confirmed by histopathological consideration. The results indicated that increased levels of hepatic LP and FRAP and SOD activity were reversed in the rats treated with oils. In addition, the depleted GSH were compensated with the oil treatments. The protective effect of the oils was further confirmed by the histophatological examination carried out on liver biopsies. The data pointed out that H. scabrum oil could modulate the hepatic toxicity induced by the APAP through adjusting the oxidative stress/antioxidant parameters and could be of potential candidate for the treatment of acetaminophen induced oxidative stress liver damages.
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