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Antioxidant Properties and Inhibitory Effects of Satureja Khozestanica Essential Oil on Ldl Oxidation Induced-Cuso4 in Vitro Publisher Pubmed



Bagheri S1 ; Ahmadvand H1, 2 ; Khosrowbeygi A1 ; Ghazanfari F1 ; Jafari N3 ; Nazem H4 ; Hosseini RH4
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry, Lorestan University of Medical Sciences, Khoramabad, Iran
  2. 2. Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran
  3. 3. Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department Biology and Biochemistry, Payame Noor University, Tehran, Iran

Source: Asian Pacific Journal of Tropical Biomedicine Published:2013


Abstract

Objective: To assess various antioxidative activities of Satureja khozestanica essential oil (SKE) and its effect on oxidation of low density lipoprotein (LDL) induced by CuSO4 in vitro by monitoring the formation of conjugated dienes and malondialdehyde (MDA). Methods: The formation of conjugated dienes, lag time and MDA were measured. Inhibition of this Cu-induced oxidation was studied in the presence of several concentrations of SKE. Also total antioxidant activity and free radical scavenging of SKE were determinated. Results: It was demonstrated that SKE was able to inhibit LDL oxidation and decrease the resistance of LDL against oxidation. The inhibitory effects of SKE on LDL oxidation were dose-dependent at concentrations ranging from 50 to 200 μg/mL. Total antioxidant capacity of SKE was (3.20±0.40) nmol of ascorbic acid equivalents/g SKE. The SKE showed remarkable scavenging activity on 2, 2-diphenyl-picrylhydrazyl, IC50 (5.30±0.11) ng/mL. Conclusions: This study shows that SKE is a source of potent antioxidants and prevents the oxidation of LDL in vitro and it may be suitable for use in food and pharmaceutical applications. © 2013 Asian Pacific Tropical Biomedical Magazine.
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