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Antispasmodic Effect of Three Fractions of Hydroalcoholic Extract of Pycnocycla Spinosa Publisher Pubmed



Sadraei H1 ; Asghari G2 ; Hekmatti AA1, 2
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, Sch. of Pharm./Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, Sch. of Pharm./Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Iran

Source: Journal of Ethnopharmacology Published:2003


Abstract

Hydroalcoholic extract of Pycnocycla spinosa was shown to have spasmolytic action in vitro and antidiarroheal effect in vivo. The hydroalcoholic extract of P. spinosa is composed of alkaloid-, flavonoid- and saponin-rich components. These components were separated by fractional separation technique. The pharmacological objective of this study was to look for relaxant effect of these components of hydroalcoholic extract of P. spinosa on rat isolated ileum contractions. The alkaloid-, flavonoid- and saponin-rich fractions of P. spinosa inhibited the response to 80mM KCl in a concentration-dependent manner. The alkaloid-rich fraction was the most and saponin-rich fraction the least effective relaxant of ileum contractions. The alkaloid-rich fraction also inhibited the response to acetylcholine (ACh) and 5-hydroxytryptamine (5-HT). From this study, it can be concluded that the antispasmodic action of hydroalcoholic extract of P. spinosa could be due to components in the alkaloid-rich fraction and to a lesser extent, to its flavonoid-rich fraction. © 2003 Elsevier Science Ireland Ltd. All rights reserved.
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