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Composition of the Essential Oil of Asa-Foetida and Its Spasmolytic Action



Sadraei H1 ; Ghannadi A2 ; Malekshahi K1
Authors
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Authors Affiliations
  1. 1. Department of Pharmacology, Sch. of Pharm./Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, Sch. of Pharm./Pharmaceutical Sci., Isfahan Univ. of Medical Sciences, Isfahan, Iran

Source: Saudi Pharmaceutical Journal Published:2003

Abstract

Oleo-gum resin of Ferula assa-foetida L. has been used in folk medicine as an spasmolytic remedy for abdominal cramps and spasms in some parts of Iran. However, so far its pharmacological effects on gastrointestinal tract has not been studied. The aim of this study was to analyse the components as well as to look for relaxant effect of F. assa-foetida essential oil (FAEO) on rat isolated ileum contractions induced by KCl, acetylcholine (ACh) and 5-hydroxytryptamine (5-HT). FAEO inhibited the response to KCl (80mM), ACh (320nM) and 5-HT (1.28μM) in a concentration-dependent manner. The inhibitory effect of FAEO on KCl contractions was achieved at a lower concentration (IC50=5.8±1.1 nl/ml) in comparison with the effect on ACh and 5-HT contractions. This research shows that FAEO is a relaxant of rat ileum. As the inhibition of contractile over-activity of the ileum is the base of the treatment of some gastro-intestinal disorders such as diarrhoea, this study support the potential spasmolytic activity of this herbal remedy.
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