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The Effects of Statins on Respiratory Symptoms and Pulmonary Fibrosis in Covid-19 Patients With Diabetes Mellitus: A Longitudinal Multicenter Study Publisher Pubmed



Sadeghdoust M1 ; Aligolighasemabadi F1 ; Dehesh T2 ; Taefehshokr N3 ; Sadeghdoust A4 ; Kotfis K5 ; Hashemiattar A6 ; Ravandi A7 ; Aligolighasemabadi N8 ; Vakili O9 ; Grabarek B10, 11, 12 ; Staszkiewicz R10, 13 ; Los MJ14, 15 ; Mokarram P15 Show All Authors
Authors
  1. Sadeghdoust M1
  2. Aligolighasemabadi F1
  3. Dehesh T2
  4. Taefehshokr N3
  5. Sadeghdoust A4
  6. Kotfis K5
  7. Hashemiattar A6
  8. Ravandi A7
  9. Aligolighasemabadi N8
  10. Vakili O9
  11. Grabarek B10, 11, 12
  12. Staszkiewicz R10, 13
  13. Los MJ14, 15
  14. Mokarram P15
  15. Ghavami S15, 16, 17, 18, 19
Show Affiliations
Authors Affiliations
  1. 1. Department of Internal Medicine, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran
  2. 2. Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, ON, Canada
  4. 4. Department of Internal Medicine, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  5. 5. Department of Anesthesiology, Intensive Therapy and Acute Intoxications, Pomeranian Medical University in Szczecin, Szczecin, Poland
  6. 6. Department of Radiology, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran
  7. 7. Institute of Cardiovascular Sciences, Sr. Boniface Research Centre, University of Manitoba, Winnipeg, Canada
  8. 8. Department of Internal Medicine, School of Medicine, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  9. 9. Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Histology, Cytophysiology and Embryology, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, Zabrze, Poland
  11. 11. Department of Gynaecology and Obstetrics, Faculty of Medicine in Zabrze, Academy of Silesia in Katowice, Zabrze, Poland
  12. 12. Laboratory of Molecular Biology and Virology, GynCentrum, Katowice, Poland
  13. 13. Department of Neurosurgery, 5Th Military Clinical Hospital with the SP ZOZ Polyclinic in Krakow, Krakow, Poland
  14. 14. Biotechnology Center, Silesian University of Technology, Gliwice, Poland
  15. 15. Autophagy Research Center, Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
  16. 16. Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Canada
  17. 17. Faculty of Medicine in Zabrze, University of Technology in Katowice, Academia of Silesia, Zabrze, Poland
  18. 18. Research Institute of Oncology and Hematology, Cancer Care, Manitoba University of Manitoba, Winnipeg, Canada
  19. 19. Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, Canada

Source: Archivum Immunologiae et Therapiae Experimentalis Published:2023


Abstract

The aim of this prospective cohort study was to explore the effect of statins on long-term respiratory symptoms and pulmonary fibrosis in coronavirus disease 2019 (COVID-19) patients with diabetes mellitus (DM). Patients were recruited from three tertiary hospitals, categorized into Statin or Non-statin groups, and assessed on days 0, 28, and 90 after symptoms onset to record the duration of symptoms. Pulmonary fibrosis was scored at baseline and follow-up time points by high-resolution computed tomography scans. Each group comprised 176 patients after propensity score matching. Data analysis revealed that the odds of having cough and dyspnea were significantly higher in the Non-statin group compared to the Statin group during the follow-up period. Overall, there was no significant difference in the change in pulmonary fibrosis score between groups. However, Non-statin patients with > 5 years of DM were more likely to exhibit a significantly higher fibrosis score during the follow-up period as compared to their peers in the Statin group. Our results suggest that the use of statins is associated with a lower risk of developing chronic cough and dyspnea in diabetic patients with COVID-19, and may reduce pulmonary fibrosis associated with COVID-19 in patients with long-term (> 5 years) DM. Graphical Abstract: [Figure not available: see fulltext.]. © 2023, The Author(s).
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