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Association of Foods Enriched in Conjugated Linoleic Acid (Cla) and Cla Supplements With Lipid Profile in Human Studies: A Systematic Review and Meta-Analysis Publisher Pubmed



Derakhshanderishehri SM1 ; Mansourian M2 ; Kelishadi R3 ; Heidaribeni M4
Authors
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Authors Affiliations
  1. 1. Food Security Research Center, Department of Clinical Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Child Growth and Development Research Center, Research Institute for Primary Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, 81754, Iran

Source: Public Health Nutrition Published:2015


Abstract

Objective: The present study aimed to review the association of conjugated linoleic acid (CLA) consumption in two forms, foods enriched in CLA and CLA supplements, with serum lipid profile in human studies. Design: Systematic review and meta-analysis. Setting: Search process was conducted in PubMed, Cochrane Library, Google Scholar, Scopus and Science Direct. Clinical trials that investigated the association of CLA intakes either in the form of supplements or enriched foods with lipid profile in healthy adults were included. All outcomes were recorded as continuous variables, and the effect size was measured by analysis of the mean and standard deviation before and after the intervention for case and control groups. Subjects: Healthy adult population. Results: CLA supplementation was associated with a significant decrease in LDL cholesterol (mean difference=-0·218; 95% CI -0·358, -0·077; P=0·002), a non-significant decrease in HDL cholesterol (mean difference=-0·051; 95% CI -0·188, 0·086; P=0·468), a non-significant increase in total cholesterol (mean difference=0·009; 95% CI -0·128, 0·146; P=0·896) and a non-significant decrease in TAG (mean difference=-0·065; 95% CI -0·20, 0·07; P=0·344). Foods enriched with CLA were associated with significantly decreased LDL cholesterol (mean difference=-0·231; 95% CI -0·438, -0·024; P=0·028), non-significantly increased HDL-C (mean difference=0·075; 95% CI -0·121, 0·270; P=0·455), non-significantly decreased total cholesterol (mean difference=-0·158; 95% CI -0·349, 0·042; P=0·124) and non-significantly decreased TAG (mean difference=-0·078; 95% CI -0·274, 0·117; P=0·433). Conclusions: According to our analysis, consumption of foods enriched with CLA or CLA supplements has favourable effects on LDL cholesterol levels. Copyright © The Authors 2014.
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