Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Thermal Treating of Acrylic Matrices As a Tool for Controlling Drug Release Publisher Pubmed



Hasanzadeh D1 ; Ghaffari S2 ; Monajjemzadeh F1 ; Alhallak MHDK3 ; Soltani G1 ; Azarmi S3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 51664, Iran
  2. 2. Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746, Iran
  3. 3. Faculty of Pharmacy, University of Alberta, Edmonton, AB T6G 2N8, Canada
  4. 4. Research Centre for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz 51664, Iran

Source: Chemical and Pharmaceutical Bulletin Published:2009


Abstract

The purpose of the present study was to investigate the effect of thermal-treating on the release of ibuprofen from the granules prepared using aqueous dispersions of Eudragit. To accomplish this goal, different formulations were prepared using wet granulation method containing two different types of Eudragit aqueous dispersions, RS30D, RL30D and Avicel as filler. Tablets were prepared using direct compression method. The prepared tablets were thermally treated at 50 and 70°C for 24 h. The drug release from tablets was assessed before and after thermal-treating. The results of release study showed that, thermally-treating the tablets at the temperatures higher than glass transition temperature (Tg) of the polymer can decrease the drug release from matrices. For mechanistic evaluation of the effect of thermal-treating, powder X-ray diffraction (XPD), scanning electron microscopy (SEM), differential scanning calorimeter (DSC), Fourier transform infrared (FT-IR) and helium pycnometer have been employed. The SEM graphs showed that the tablets have smoother surface with less porosity after thermal-treating. FT-IR spectra showed no change in the spectrum of thermally-treated tablet compared to control. In DSC graphs, no crystalline change was seen in the heat-treated samples of ibuprofen tablets, but decreased and widened peak size were related to the probable formation of solid solution of ibuprofen in Eudragit matrix. The results of helium pycnometer showed a significant decrease in the total porosity of some heat-treated samples. This study revealed the importance of thermal treating on the drug release from sustained release tablets containing Eudragit polymer. © 2009 Pharmaceutical Society of Japan.
Related Docs
View other Related Docs
1. Crystal Engineering of Ibuprofen Using Starch Derivatives in Crystallization Medium to Produce Promising Ibuprofen With Improved Pharmaceutical Performance, RSC Advances (2015)
2. Preparation and Characterization of a Sustained Release Buccoadhesive System for Delivery of Terbutaline Sulfate, Research in Pharmaceutical Sciences (2013)
3. Production of a New Platform Based on Fumed and Mesoporous Silica Nanoparticles for Enhanced Solubility and Oral Bioavailability of Raloxifene Hcl, IET Nanobiotechnology (2019)
4. Design, Formulation, and Physicochemical Evaluation of Montelukast Orally Disintegrating Tablet, International Journal of Preventive Medicine (2016)
5. Development and Physical Characterization of a Periodontal Bioadhesive Gel of Metronidazole, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2002)
6. Evaluation of Trigonella Foenum-Graecum Seeds Gum As a Novel Tablet Binder, International Journal of Pharmacy and Pharmaceutical Sciences (2012)
7. Preparation and Pharmaceutical Evaluation of Glibenclamide Slow Release Mucoadhesive Buccal Film, Research in Pharmaceutical Sciences (2014)
8. Use of Enteric Polymers for Production of Microspheres by Extrusion-Spheronization, Pharmaceutica Acta Helvetiae (1997)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (22)
Abolfazl Aslani (5)
Other Related Docs
9. Preparation and Characterization of Solid Dispersions of Celecoxib Obtained by Spray-Drying Ethanolic Suspensions Containing Pvp-K30 or Isomalt, Journal of Drug Delivery Science and Technology (2018)
10. Development and Evaluation of Sustained-Release Propranolol Wax Microspheres, Journal of Microencapsulation (2001)
11. Formulation, Optimization and in Vitro Evaluation of Rapid Disintegrating and Mucoadhesive Sublingual Tablets of Lorazepam, Farmacia (2015)
12. Physicochemical, Pharmacodynamic and Pharmacokinetic Characterization of Soluplus Stabilized Nanosuspension of Tacrolimus, Current Drug Delivery (2017)
13. Preparation and Physicochemical Evaluation of Oral Disintegrated Tablet Containing Dicyclomine Hydrochloride, Journal of Reports in Pharmaceutical Sciences (2018)
14. Enhancement of Dissolution Rate of Fenofibrate by Spray Drying Technique: Comparison of Eudragit E-100, Solutol® Hs15 and Hydroxypropyl Cellulose As Carriers, Farmacia (2015)
15. Pharmaceutical Evaluation of Ziziphus Jujuba Mucoadhesive Buccal Film, Journal of Reports in Pharmaceutical Sciences (2015)
16. Effects of Concentration, Temperature and Polymer Type on Drug Release From Montmorillonite-Donepezil Nanocomposites, Journal of Isfahan Medical School (2013)
17. Development of Bioadhesive Chitosan Gels for Topical Delivery of Lidocaine, Scientia Pharmaceutica (2006)
18. Use of Natural Gums and Cellulose Derivatives in Production of Sustained Release Metoprolol Tablets, Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents (2006)
19. Polyelectrolyte Complexes of Chitosan for Production of Sustained Release Tablets of Bupropion Hcl, Farmacia (2015)
20. Enhancement of Solubility and Antidiabetic Effects of Repaglinide Using Spray Drying Technique in Stz-Induced Diabetic Rats, Pharmaceutical Development and Technology (2017)
21. Preparation and Characterization of Celecoxib Solid Dispersions; Comparison of Poloxamer-188 and Pvp-K30 As Carriers, Iranian Journal of Basic Medical Sciences (2014)
22. Influence of Different Solid-Dispersion Techniques Upon the Release of Dimenhydrinate From Chewing-Gum Formulations, Scientia Pharmaceutica (2002)
23. Dual Thermo- and Ph-Responsive Poly(N-Isopropylacrylamide-Co-(2-Dimethylamino) Ethyl Methacrylate)-G-Peg Nanoparticle System and Its Potential in Controlled Drug Release, Polymer Bulletin (2020)
24. Preparation and Evaluation of Theophylline Sustained Release Microcapsules Using Coacervation, Journal of Dispersion Science and Technology (2012)
25. Comparing the Drug Loading and Release of Silica Aerogel and Pva Nano Fibers, Journal of Non-Crystalline Solids (2019)
26. Use of Hydrophilic Natural Gums in Formulation of Sustained-Release Matrix Tablets of Tramadol Hydrochloride, AAPS PharmSciTech (2006)
27. Development and Characterization of Buccoadhesive Nifedipine Tablets, European Journal of Pharmaceutics and Biopharmaceutics (2002)
28. Preparation and in Vitro Evaluation of Sustained-Release Matrix Tablets of Flutamide Using Synthetic and Naturally Occurring Polymers, Iranian Journal of Pharmaceutical Research (2008)
29. Influence of Β - Cyclodextrin Complexation on Lovastatin Release From Osmotic Pump Tablets (Opt), Daru (2007)
30. Design, Formulation, and Evaluation of a Herbal Gel Contains Melissa, Sumac, Licorice, Rosemary, and Geranium for Treatment of Recurrent Labial Herpes Infections, Dental Research Journal (2018)
31. Design, Formulation and Evaluation of Its Physiochemical Properties of Acetaminophen, Ibuprofen and Caffeine As Effervescent Tablet, Journal of Reports in Pharmaceutical Sciences (2016)
32. Formulation, Characterization and Physicochemical Evaluation of Ranitidine Effervescent Tablets, Advanced Pharmaceutical Bulletin (2013)
33. Solid Carriers for Improved Solubility of Glipizide in Osmotically Controlled Oral Drug Delivery System, Drug Development and Industrial Pharmacy (2007)
34. Preparation, Characterization and Optimization of Glipizide Controlled Release Nanoparticles, Research in Pharmaceutical Sciences (2014)
35. Formulation and Evaluation of Co-Amoxiclav 228 and 312 Mg Dispersible Tablets, Journal of Reports in Pharmaceutical Sciences (2016)
36. Preparation and Characterization of Celecoxib Dispersions in Soluplus®: Comparison of Spray Drying and Conventional Methods, Iranian Journal of Pharmaceutical Research (2015)
37. Preparation and Characterization of Metoprolol Controlled-Release Solid Dispersions, Drug Delivery (2006)
38. Design, Optimization and Evaluation of Orally Disintegrating Tablet of Meloxicam Using Its Menthol Based Solid Dispersions, Current Drug Delivery (2017)
39. Screening the Most Effective Variables on Physical Properties of Folate-Targeted Dextran/Retinoic Acid Micelles by Taguchi Design, Journal of Nanomaterials (2012)
40. Preparation and Characterization of an Injectable Thermosensitive Hydrogel for Simultaneous Delivery of Paclitaxel and Doxorubicin, Research in Pharmaceutical Sciences (2018)
41. Ordered Mesoporous Magnesium Silicate With Uniform Nanochannels As a Drug Delivery System: The Effect of Calcination Temperature on Drug Delivery Rate, Ceramics International (2016)
42. Anomalous Dissolution Behavior of Celecoxib in Pvp/Isomalt Solid Dispersions Prepared Using Spray Drier, Materials Science and Engineering C (2017)
43. Double-Walled Microspheres Loaded With Meglumine Antimoniate: Preparation, Characterization and in Vitro Release Study, Drug Development and Industrial Pharmacy (2014)