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Toll Like Receptor 2 and 4 Expression in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients Pubmed



Hasheminia SJ1, 6 ; Zarkeshesfahani SH2 ; Tolouei S3 ; Shaygannejad V4 ; Shirzad H5 ; Chaleshtory MH1, 6
Authors
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Authors Affiliations
  1. 1. Cellular and Molecular Research Center, School of Medicine, Shahre Kord University of Medical Sciences, Shahre Kord, Iran
  2. 2. Department of Biology, School of Sciences, University of Isfahan, Iran
  3. 3. Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Iran
  4. 4. Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Immunology, School of Medicine, Shahre Kord University of Medical Sciences, Iran
  6. 6. Cellular and Molecular Research Center, School of Medicine, Shahre Kord University of Medical Sciences, Shahre Kord, Iran

Source: Iranian Journal of Immunology Published:2014


Abstract

Background: Multiple sclerosis (MS) is a T cell mediated autoimmune disease with unknown etiology. Appropriate MS therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. Ligation of TLR-2 and TLR-4 stimulates the production of several cytokines leading to CNS autoimmunity and neurodegenerative diseases. Objective: To find a relationship between MS disability and TLR-2 and TLR-4 expression on mononuclear cells in the blood of MS patients. Methods: Forty-five new case (NC) MS patients (33 females and 12 males) and 45 age and gender-matched healthy controls (HC) were recruited to the study. PBMCs were prepared and the expressions of TLR-2 and TLR-4 were assessed by flowcytometry technique using appropriate monoclonal antibodies. Results: Our results showed that the expression of TLR-2 and TLR-4 proteins in the patients group was significantly higher than that of healthy controls. TLR-2 but not TLR-4 was correlated with expanded disability status scale (EDSS) scores. Conclusion: High expressions of TLR-2 and TLR-4 may represent a state of innate immune activation in patients with MS. © 2014, Shiraz University of Medical Sciences.
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