Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of High Dose Vitamin D Intake on Interleukin-17 Levels in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Publisher Pubmed



Toghianifar N1 ; Ashtari F1, 2 ; Zarkeshesfahani SH3 ; Mansourian M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Isfahan Neuroscience Research Centre, Iran
  3. 3. University of Isfahan, Department of Biology, Isfahan, Iran
  4. 4. Department of Biostatistics and Epidemiology, Health School, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Neuroimmunology Published:2015


Abstract

Background: Vitamin D has immunomodulatory effects in multiple sclerosis (MS). Vitamin D acts through various mechanisms such as secretion of cytokines. Interleukin-17 (IL-17) is a critical interleukin in inflammatory response in MS. Objective: This study assessed the effect of oral high dose vitamin D intake on IL-17 levels in MS patients in a double blind randomized clinical trial. Methods: 94 patients with a diagnosis of relapsing remitting multiple sclerosis (RRMS) were randomized to two groups. One group received 50,000 IU vitamin D3 every five days for 12. weeks. The other group was given placebo. Both groups received interferon-β (IFN-β) treatment. Serum levels of IL-17 were measured at the beginning of the study and after 12. weeks. Results: IL-17 serum levels were 56.75. ±. 28.72. pg/ml and 30.31. ±. 75.85. pg/ml in the intervention and placebo group at the beginning of the study, respectively (Median. ±. IQR, p = 0.338). After 12. weeks, IL-17 levels were 58.93. ±. 67.93. pg/ml and 46.13. ±. 94.70. pg/ml in the intervention and placebo group, respectively (Median. ±. IQR, p = 0.960). The multiple linear regression analysis indicated that the consumption of vitamin D3 was positively and significantly associated with the logarithm of IL-17 measures (β = 1.719; p = 0.002 and R2 = 0.91), adjusted by EDSS scores. Conclusion: IL-17 levels showed significant change in RRMS patients after receiving high dose vitamin D3 for 12. weeks. © 2015 Elsevier B.V.
Related Docs
View other Related Docs
1. Vitamin D Supplementation Could Limit T Helper-17 Response in Multiple Sclerosis, Clinical and Experimental Neuroimmunology (2014)
2. Short-Term Effect of High-Dose Vitamin D on the Level of Interleukin 10 in Patients With Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, NeuroImmunoModulation (2015)
3. High Dose Vitamin D Intake and Quality of Life in Relapsing-Remitting Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial, Neurological Research (2016)
4. Iranian Consensus on Use of Vitamin D in Patients With Multiple Sclerosis, BMC Neurology (2016)
5. Effects of Vitamin D on Retinal Nerve Fiber Layer in Vitamin D Deficient Patients With Optic Neuritis: Preliminary Findings of a Randomized, Placebo-Controlled Trial, Journal of Research in Medical Sciences (2015)
6. Preventive Effect of Vitamin D3 Supplementation on Conversion of Optic Neuritis to Clinically Definite Multiple Sclerosis: A Double Blind, Randomized, Placebo-Controlled Pilot Clinical Trial, Acta Neurologica Belgica (2013)
7. Efficacy of Adding Vitamin D Supplementation to Interferon Β-1 in Multiple Sclerosis, Journal of Isfahan Medical School (2016)
8. The Beneficial Effects of Vitamin D3 on Reducing Antibody Titers Against Epstein-Barr Virus in Multiple Sclerosis Patients, Cellular Immunology (2015)
Experts (# of related papers)
View all Related Experts
Vahid Shaygannejad (52)
Masoud Etemadifar (51)
Other Related Docs
9. Serum Levels of 25(Oh) Vitamin D3 and Clinical Manifestation of First Demyelinating Attack, Journal of Isfahan Medical School (2018)
10. The Relation Between Vitamin D Status With Fatigue and Depressive Symptoms of Multiple Sclerosis, Journal of Research in Medical Sciences (2013)
11. Decreased Serum Levels of Interleukin-35 Among Multiple Sclerosis Patients May Be Related to Disease Progression, Journal of Biological Regulators and Homeostatic Agents (2018)
12. Does Lipoic Acid Consumption Affect the Cytokine Profile in Multiple Sclerosis Patients: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial, NeuroImmunoModulation (2014)
13. The Role of Cobalamin on Interleukin 10, Osteopontin, and Related Micrornas in Multiple Sclerosis, Iranian Journal of Allergy, Asthma and Immunology (2022)
14. The Levels of Soluble Forms of Cd21 and Cd83 in Multiple Sclerosis, Journal of Neuroimmunology (2018)
15. Association Between Acute Infectious Mononucleosis and Vitamin D Deficiency, Viral Immunology (2016)
16. Serum Levels of Interleukin-6 and Vitamin D at the Onset of Multiple Sclerosis and Neuromyelitis Optica: A Pilot Study, Journal of Research in Medical Sciences (2022)
17. Research Paper: The Association Between Salt and Potassium Intake With Multiple Sclerosis, Caspian Journal of Neurological Sciences (2019)
18. Cytokine Gene Expression in Newly Diagnosed Multiple Sclerosis Patients, Iranian Journal of Allergy, Asthma and Immunology (2015)
19. The Effects of Vitamin D Supplementation on Inflammatory Biomarkers in Patients With Abnormal Glucose Homeostasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2021)
20. 25-Hydroxyvitamin D Concentrations in Patients With Optic Neuritis As a Clinically Isolated Syndrome and Healthy Controls, International Journal of Preventive Medicine (2012)
21. A Comparative Study of 25 (Oh) Vitamin D Serum Levels in Patients With Multiple Sclerosis and Control Group in Isfahan, Iran, International Journal of Preventive Medicine (2010)
22. Vitamin D3 Induced Decrease in Il-17 and Malondialdehyde, and Increase in Il-10 and Total Antioxidant Capacity Levels in Patients With Irritable Bowel Syndrome, Iranian Journal of Immunology (2018)
23. Evaluation of Plasma Osteopontin Level in Relapsing- Remitting Multiple Sclerosis Patients Compared to Healthy Subjects in Isfahan Province, International Journal of Neuroscience (2020)
24. Comparison of Expression Levels of Mir-29B-3P and Mir-326 in T Helper-1 and T Helper-17 Cells Isolated From Responsive and Non-Responsive Relapsing-Remitting Multiple Sclerosis Patients Treated With Interferon-Beta, Iranian Journal of Allergy, Asthma and Immunology (2020)
25. Toll Like Receptor 2 and 4 Expression in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients, Iranian Journal of Immunology (2014)
26. The Frequencies of Peripheral Blood Cd5+Cd19+ B Cells, Cd3−Cd16+Cd56+ Nk, and Cd3+Cd56+ Nkt Cells and Serum Interleukin-10 in Patients With Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder, Allergy, Asthma and Clinical Immunology (2022)
27. Biased Treg/Th17 Balance Away From Regulatory Toward Inflammatory Phenotype in Relapsed Multiple Sclerosis and Its Correlation With Severity of Symptoms, Journal of Neuroimmunology (2013)
28. The Role of Cobalamin in Multiple Sclerosis: An Update, Inflammation (2024)
29. Il-23 Plasma Level Measurement in Relapsing Remitting Multiple Sclerosis (Rrms) Patients Compared to Healthy Subjects, Immunological Investigations (2015)
30. Interleukin 18 Polymorphisms and Its Serum Level in Patients With Multiple Sclerosis, Annals of Indian Academy of Neurology (2019)
31. Il-27 Plasma Level in Relapsing Remitting Multiple Sclerosis Subjects: The Double-Faced Cytokine, Journal of Immunoassay and Immunochemistry (2016)
32. Vitamin D Level in Iranian Patients With Neuromyelitis Optica, Journal of Isfahan Medical School (2021)
33. Significant Immunomodulatory and Hepatoprotective Impacts of Silymarin in Ms Patients: A Double-Blind Placebo-Controlled Clinical Trial, International Immunopharmacology (2021)
34. Correlation of Midkine Serum Level With Pro- and Anti-Inflamatory Cytokines in Multiple Sclerosis, Iranian Journal of Immunology (2014)
35. Serum Level of Interleukin 36 in Patients With Multiple Sclerosis, Journal of Immunoassay and Immunochemistry (2018)
36. The Association Between Vitamin D Intake With Inflammatory and Biochemical Indices and Mortality in Critically Ill Patients With Covid-19: A Case-Control Study, Immunity, Inflammation and Disease (2023)
37. Effect of Vitamin D Supplementation on C-Reactive Protein in Patients With Nonalcoholic Fatty Liver, International Journal of Preventive Medicine (2014)
38. The Role of Vitamin D in the Age of Covid-19: A Systematic Review and Meta-Analysis, International Journal of Clinical Practice (2021)
39. Interleukin-33 Plasma Levels in Patients With Relapsing-Remitting Multiple Sclerosis, Biomolecular Concepts (2017)
40. Evaluating the Effect of Adding Fish Oil to Fingolimod on Tnf-Α Il1β Il6, and Ifn-Γ in Patients With Relapsing-Remitting Multiple Sclerosis: A Double-Blind Randomized Placebo-Controlled Trial, Clinical Neurology and Neurosurgery (2017)
41. Vitamin D Supplementation for Premenstrual Syndrome-Related Inflammation and Antioxidant Markers in Students With Vitamin D Deficient: A Randomized Clinical Trial, Scientific Reports (2019)
42. Th1, Th2 and Th17 Cytokine Profile in Patients With Multiple Sclerosis Following Treatment With Rapamycin, Iranian Journal of Immunology (2016)
43. Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women With Anxiety: A Randomized Clinical Trial, International Journal of Preventive Medicine (2019)
44. Rituximab and Glatiramer Acetate in Secondary Progressive Multiple Sclerosis: A Randomized Clinical Trial, Acta Neurologica Scandinavica (2021)
45. Investigating the Occurrence of Femoral Head Avascular Necrosis in Patient With Multiple Sclerosis Treated With Interferon-Beta, Journal of Isfahan Medical School (2018)
46. The Comparative Analysis of Serum Levels of Midkine in Patients With Multiple Sclerosis and Control Group, Journal of Isfahan Medical School (2013)
47. Genetic Variations of Vitamin D Receptor and Vitamin D Supplementation Interaction in Relation to Serum Vitamin D and Metabolic Traits: A Systematic Review and Meta-Analysis, International Journal for Vitamin and Nutrition Research (2023)
48. Comparison of Interferon Beta Products and Azathioprine in the Treatment of Relapsing-Remitting Multiple Sclerosis, Journal of Neurology (2007)
49. Prognostic Value of Intrathecal Igg Synthesis in Multiple Sclerosis: A Study in 54 Patients, Tehran University Medical Journal (2008)
50. The in Vitro Effects of Vitamin 1, 25(Oh) 2 D3 on Expression of Cytokines: In New-Onset Systemic Lupus Erythematosus Patients, Lupus (2022)