Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Anti-Cancer Activity of Chrysin in Cancer Therapy: A Systematic Review Publisher



Salari N1 ; Faraji F2 ; Jafarpour S3 ; Faraji F2 ; Rasoulpoor S5 ; Dokaneheifard S6 ; Mohammadi M7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran
  6. 6. Department of Human Genetics, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, 33136, FL, United States
  7. 7. Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran

Source: Indian Journal of Surgical Oncology Published:2022


Abstract

Chrysin is a natural bioactive compound that is extracted from many trees, honey, and propolis. Chrysin has several pharmacological activities such as anti-inflammatory, anti-cancer, and antioxidant properties. This study was performed to evaluate the anti-cancer activities of chrysin in cancer therapy. The present study was conducted by systematic review of studies published up to August 2021. Related studies were identified by searching Web of Science (WoS), PubMed, Science Direct, SID, MagIran, Scopus, and Google Scholar databases. The keywords of chrysin, cancer, anti-cancer, and cancer therapy were used for searching. The quality of the studies was assessed by the CONSORT checklist. A total of 21 studies were identified. The results of studies showed that chrysin has an anticancer effect by stimulating apoptosis in a wide range of human cells and rats. Chrysin is also an important factor in inhibiting tumor growth and neoplasticity. Chrysin inhibits the growth and proliferation of cancer cells by inducing cytotoxic effects. Therefore, due to the antitumor effects of chrysin and its safety and non-toxicity towards normal cells, this compound can be considered as an adjuvant along with chemotherapeutic agents in cancer treatment. © 2022, The Author(s), under exclusive licence to Indian Association of Surgical Oncology.
Related Docs
View other Related Docs
1. The Role of Natural Products As Inhibitors of Jak/Stat Signaling Pathways in Glioblastoma Treatment, Oxidative Medicine and Cellular Longevity (2022)
2. A Comparison of Thiazolyl Blue (Mtt) Versus Sulforhodamine B (Srb) Assay in Assessment of Antiproliferative Effect of Bromelain on 4T1, Ags, and Pc3 Cancer Cell Lines, Journal of Isfahan Medical School (2017)
3. Investigating the Effect of Razurin Loaded Mesoporous Silica Nanoparticles Enwrapped With Chitosan-Folic Acid on Breast Tumor Regression in Balb/C Mice, International Journal of Biological Macromolecules (2025)
4. Cytotoxicity Effect of Pineapple Extract on Breast Cancer Cells (4T1), Journal of Isfahan Medical School (2016)
5. Melatonin As a Regulator of Apoptosis in Leukaemia: Molecular Mechanism and Therapeutic Perspectives, Frontiers in Pharmacology (2023)
6. Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells, Journal of Medical Signals and Sensors (2019)
7. Persianolide-A, an Eudesmanolide-Type Sesquiterpene Lactone From Artemisia Kopetdaghensis, Induces Apoptosis by Regulating Erk Signaling Pathways, Research in Pharmaceutical Sciences (2024)
8. Evaluation of Anticancer Effects of Cerium Oxide Nanoparticles on Mouse Fibrosarcoma Cell Line, Journal of Cellular Physiology (2019)
Experts (# of related papers)
View all Related Experts
Daryoush Shahbazi-Gahrouei (4)
Abbas Jafarian (4)
Other Related Docs
9. Cytotoxic Activities of Euphorbia Kopetdaghi Against Ovcar-3 and Ej-138 Cell Lines, Journal of HerbMed Pharmacology (2015)
10. Natural and Herbal Compounds Targeting Breast Cancer, a Review Based on Cancer Stem Cells, Iranian Journal of Basic Medical Sciences (2020)
11. Cytotoxic Effects of the Extracts of Iranian Taxus Baccata and Cupressus Horizentalis on Cancer Cells, Iranian Journal of Pharmaceutical Research (2003)
12. Comparison of Anticancer Effects of Hydroalcoholic Extracts of Camellia Sinensis and Lepidium Sativum L on Hela Cell Line, International Journal of Cancer Management (2020)
13. Curcumin: A New Candidate for Melanoma Therapy?, International Journal of Cancer (2016)
14. Cytotoxic Effects of Chloroform and Hydroalcoholic Extracts of Aerial Parts of Cuscuta Chinensis and Cuscuta Epithymum on Hela, Ht29 and Mda-Mb-468 Tumor Cells, Research in Pharmaceutical Sciences (2014)
15. Bromelain Inhibitory Effect on Colony Formation: An in Vitro Study on Human Ags, Pc3, and Mcf7 Cancer Cells, Journal of Medical Signals and Sensors (2019)
16. Quercetin Modulates Signal Transductions and Targets Non-Coding Rnas Against Cancer Development, Cellular Signalling (2023)
17. The Cytotoxic and Pro-Apoptotic Effects of Various Extracts of Allium Giganteum on Mcf-7 and Hela Cell Lines, Journal of Isfahan Medical School (2021)
18. Mitochondrion: Main Organelle in Orchestrating Cancer Escape From Chemotherapy, Cancer Reports (2024)
19. Evaluation of in Vitro Cytotoxic Effects of Juniperus Foetidissima and Juniperus Sabina Extracts Against a Panel of Cancer Cells, Iranian Journal of Pharmaceutical Research (2009)
20. Melatonin As a Promising Agent for Cancer Treatment: Insights Into Its Effects on the Wnt/Beta-Catenin Signaling Pathway, Current Medicinal Chemistry (2024)
21. Concentration- Dependent Effects of Curcumin on 5-Fluorouracil Efficacy in Bladder Cancer Cells, Asian Pacific Journal of Cancer Prevention (2017)
22. Molecular Mechanism of Apoptosis Induction by Gaillardin, a Sesquiterpene Lactone, in Breast Cancer Cell Lines: Gaillardin-Induced Apoptosis in Breast Cancer Cell Lines, Cell Biology and Toxicology (2015)
23. Effect of Cerium Lanthanide on Hela and Mcf-7 Cancer Cell Growth in the Presence of Transferrin, Research in Pharmaceutical Sciences (2010)
24. Cytotoxic Effects of Essential Oils of Some Iranian Citrus Peels, Iranian Journal of Pharmaceutical Research (2005)
25. Centaurea Cyanus Extracted 13-O-Acetylsolstitialin a Decrease Bax/Bcl-2 Ratio and Expression of Cyclin D1/Cdk-4 to Induce Apoptosis and Cell Cycle Arrest in Mcf-7 and Mda-Mb-231 Breast Cancer Cell Lines, Journal of Cellular Biochemistry (2019)