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Mir-504 Expression Level Is Increased in Multiple Sclerosis Patients Responder to Interferon-Beta Publisher Pubmed



Tahmasebivand M1, 2 ; Mousavi SR1, 2 ; Khorrami M3 ; Ayromlou H4 ; Rikhtegar R5 ; Saberi L3 ; Khademi B1, 2 ; Bahmanpour Z1, 2 ; Emamalizadeh B1
Authors

Source: Journal of Neuroimmunology Published:2020


Abstract

Multiple sclerosis is immune-mediated disease of the central nervous system characterized by demyelination in axons. IFN-β is first-line treatment of MS. Biomarkers are needed for early prediction of responders and non-responders to therapy in the first month of treatment to avoid further disabilities. In this study, we analyzed the expression level of miR-504 and miR-711 in 52 IFN-β responder patients in comparison to 53 non-responders. In the next step, the in-silico analysis was used to enrich related signaling pathways. The expression level of miR-504 was significantly higher in patients who respond to IFN-β therapy, compared with non-responders and we obtain related statistically significant KEGG molecular signaling pathways. Our findings suggest that miR-504 can be considered as a novel biomarker for response to IFN-b therapy. © 2020 Elsevier B.V.
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