A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share this content! On (X network) By

A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients Publisher

Dehdashtian E¹ ; Tabatabaeian H^{2, 3} ; Ghaedi K^{4, 5} ; Talebi A⁶ ; Adami B⁷

Show Affiliations

1. Department of Microbiology, Faculty of Biological Science, Islamic Azad University, Falavarjan Branch, Isfahan, Iran
2. Department of Biology, Division of Genetics, Faculty of Sciences, University of Isfahan, Isfahan, Iran
3. Cancer Science Institute of Singapore, National University of Singapore, 117599, Singapore
4. Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan, Iran
5. Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran
6. Department of Pathology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
7. Department of Animal and Nutritional Sciences, West Virginia University, Morgantown, 26506, WV, United States

Source: Gene Reports Published:2019

Abstract

Background: Gastric cancer is the third leading cause of cancer-related death worldwide. miR-21 is one of the non-coding RNAs drastically deregulated in gastric cancer. However, the expression of miR-21 and its association with the clinicopathological characteristics of gastric cancer patients has not been studied clearly in Iranian population. Objectives: We aimed to analyze the expression level of miR-21 in a set of fresh gastric cancer specimens and healthy control samples. The expression level of miR-21 was then analyzed to explore for the statistically significant correlations with the clinicopathological features of the samples. Methods: miR-21 expression level was quantitatively studied by RT-qPCR. The association studies between miR-21 expression and the clinical data were performed statistically. Results: miR-21 is highly expressed in gastric cancer patients regardless of H. pylori infection. This phenomenon significantly correlates with lymph node (p = 0.022) and peritoneal (p = 0.023) metastasis, stage I of gastric cancer (p = 0.021), greater curvature tumor location (p = 0.030) and bigger tumor size (p = 0.050) in gastric cancer patients in Iranian population. Conclusion: miR-21 is overexpressed in gastric cancer. This perturbation may not be mediated by H. pylori infection. © 2019

Related Docs

View other Related Docs

1. Mir-195 Down-Regulation Is a Distinctive Biomarker of Her2 Positive State in Breast Cancer, Gene Reports (2020)

2. Mir-146A Is Deregulated in Gastric Cancer, Journal of Cancer Research and Therapeutics (2019)

3. Upregulation of Mir-222 in Both Helicobacter Pylori-Infected and Noninfected Gastric Cancer Patients, Journal of Genetics (2016)

4. Construction of a Three-Component Regulatory Network of Transcribed Ultraconserved Regions for the Identification of Prognostic Biomarkers in Gastric Cancer, Journal of Cellular Biochemistry (2023)

5. Involvement of Single Nucleotide Polymorphisms in Acute Lymphoblastic Leukemia Susceptibility, Gene Reports (2020)

6. The Importance of Snps at Mirna Binding Sites As Biomarkers of Gastric and Colorectal Cancers: A Systematic Review, Journal of Personalized Medicine (2022)

7. Mir-17-92 Host Gene, Uderexpressed in Gastric Cancer and Its Expression Was Negatively Correlated With the Metastasis, Indian Journal of Cancer (2015)

8. Mir-145 and Mir20a-5P Potentially Mediate Pleiotropic Effects of Interferon-Beta Through Mitogen-Activated Protein Kinase Signaling Pathway in Multiple Sclerosis Patients, Journal of Molecular Neuroscience (2017)

Experts (# of related papers)

View all Related Experts

Parvaneh Nikpour (15)

Mohammadreza Sharifi (5)

Other Related Docs

9. Differential Expression Profile of Mir-27B, Mir-29A, and Mir-155 in Chronic Lymphocytic Leukemia and Breast Cancer Patients, Molecular Therapy Oncolytics (2020)

10. Mir-504 Expression Level Is Increased in Multiple Sclerosis Patients Responder to Interferon-Beta, Journal of Neuroimmunology (2020)

11. Connection of Mir-185 and Mir-320A Expression Levels With Response to Interferon-Beta in Multiple Sclerosis Patients, Multiple Sclerosis and Related Disorders (2020)

12. Circulating Micrornas As Potential Diagnostic Biomarkers and Therapeutic Targets in Gastric Cancer: Current Status and Future Perspectives, Current Medicinal Chemistry (2016)

13. Epigenetics and Common Non Communicable Disease, Advances in Experimental Medicine and Biology (2019)

14. Emerging Circulating Mirnas and Lncrnas in Upper Gastrointestinal Cancers, Expert Review of Molecular Diagnostics (2020)

15. Systems Biology and Machine Learning Approaches Identify Drug Targets in Diabetic Nephropathy, Scientific Reports (2021)

16. A Compound Downregulation of Srrm2 and Mir-27A-3P With Upregulation of Mir-27B-3P in Pbmcs of Parkinson’S Patients Is Associated With the Early Stage Onset of Disease, PLoS ONE (2020)

17. A Comprehensive Insight Into the Correlation Between Ncrnas and the Wnt/Β-Catenin Signalling Pathway in Gastric Cancer Pathogenesis, Cell Communication and Signaling (2023)

18. Results of Combination Chemotherapy and Radiation Therapy in Non-Metastatic Gastric Cancer in Yazd - Iran, Indian Journal of Cancer (2015)

19. Comprehensive Analysis of Ernas and Genes Involved in Gastric Cancer and Constructing a Prognostic Model Predicting the Overall Survival of Patients, Journal of Isfahan Medical School (2023)

20. A Glance at Glioblastoma Molecular Culprits Through In-Silico Analysis, Gene Reports (2021)

21. Long Noncoding Rnas in Gastric Cancer Carcinogenesis and Metastasis, Briefings in Functional Genomics (2017)

22. Locked Nucleic Acid Anti-Mir-21 Inhibits Cell Growth and Invasive Behaviors of a Colorectal Adenocarcinoma Cell Line: Lna-Anti-Mir As a Novel Approach, Cancer Gene Therapy (2016)

23. Micrornas, Long Non-Coding Rnas, and Circular Rnas and Gynecological Cancers: Focus on Metastasis, Frontiers in Oncology (2023)

24. Prevalence of Stomach Cancer in Isfahan Province, Iran, The Gulf journal of oncology (2018)

25. Degradation of Mir-21 Induces Apoptosis and Inhibits Cell Proliferation in Human Hepatocellular Carcinoma, Cancer Gene Therapy (2015)

26. Inhibition of Microrna-21 Via Locked Nucleic Acid-Anti-Mir Suppressed Metastatic Features of Colorectal Cancer Cells Through Modulation of Programmed Cell Death 4, Tumor Biology (2017)

27. Augmented Expression Levels of Lncrnas Eccebpa and Uca1 in Gastric Cancer Tissues and Their Clinical Significance, Iranian Journal of Basic Medical Sciences (2017)

28. Current Status and Perspectives Regarding Lna-Anti-Mir Oligonucleotides and Microrna Mir-21 Inhibitors As a Potential Therapeutic Option in Treatment of Colorectal Cancer, Journal of Cellular Biochemistry (2017)

29. Targetome Analysis Revealed Involvement of Mir-126 in Neurotrophin Signaling Pathway: A Possible Role in Prevention of Glioma Development, Cell Journal (2018)

30. Lncarod Promotes the Proliferation and Migration of Gastric Cancer: A Bioinformatics Analysis and Experimental Validation, Functional and Integrative Genomics (2023)

31. Long Non-Coding Rnas As Potential Biomarkers or Therapeutic Targets in Gastric Cancer, Gastroenterology and Hepatology from Bed to Bench (2023)

32. The Significant Role of Micrornas in Gliomas Angiogenesis: A Particular Focus on Molecular Mechanisms and Opportunities for Clinical Application, Cellular and Molecular Neurobiology (2023)

33. Aberrant Expression of Plncrna-1 and Tug1: Potential Biomarkers for Gastric Cancer Diagnosis and Clinically Monitoring Cancer Progression, Biomarkers in Medicine (2017)

34. Therapeutic Inhibition of Microrna-21 (Mir-21) Using Locked-Nucleic Acid (Lna)-Anti-Mir and Its Effects on the Biological Behaviors of Melanoma Cancer Cells in Preclinical Studies, Cancer Cell International (2020)

35. Introduction of Lpin1 As a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer Via Integrative Bioinformatics Analysis of a Competing Endogenous Rna Network and Experimental Validation, Iranian Journal of Basic Medical Sciences (2024)

36. Comparison of Five Staging Systems of Lymph Node Metastasis in the Gastric Carcinoma, Journal of Research in Medical Sciences (2013)

37. Analysis of a Four-Component Competing Endogenous Rna Network Reveals Potential Biomarkers in Gastric Cancer: An Integrated Systems Biology and Experimental Investigation, Advanced Biomedical Research (2023)

38. Resistin and Prooxidant-Antioxidant Balance: Markers to Discriminate Acute Coronary Syndrome From Stable Angina, ARYA Atherosclerosis (2020)

39. New Insight to Il-23/Il-17 Axis in Iranian Infected Adult Patients With Gastritis : Effects of Genes Polymorphisms on Expression of Cytokines, Acta Gastro-Enterologica Belgica (2015)

40. Mir-939, As an Important Regulator in Various Cancers Pathogenesis, Has Diagnostic, Prognostic, and Therapeutic Values: A Review, Journal of the Egyptian National Cancer Institute (2024)

41. Association of Serum Microrna-21 Levels With Visfatin, Inflammation, and Acute Coronary Syndromes, Heart and Vessels (2017)

42. Alteration of Mir-21, Mir-433 and Mir-590 Tissue Expression Related to the Tgf-Β Signaling Pathway in Ulcerative Colitis Patients, Archives of Physiology and Biochemistry (2022)

43. Upregulation of Cd4+ T-Cell Derived Mir-223 in the Relapsing Phase of Multiple Sclerosis Patients, Cell Journal (2016)

44. Plasma Level of Mir-21 and Mir-451 in Primary and Recurrent Breast Cancer Patients, Breast Cancer: Targets and Therapy (2019)

45. Association Between Promoter Methylation and Expression of Thyroid Hormone Receptor Beta (Thrβ) Gene in Patients With Gastric Cancer in an Iranian Population, Journal of Gastroenterology and Hepatology (Australia) (2015)

46. Methylation and Polymorphism in Cdh1 Gene Promoter Among Patients With Diffuse Gastric Cancer, International Journal of Preventive Medicine (2022)

47. Circulating Microrna-192 As a Diagnostic Biomarker in Human Chronic Lymphocytic Leukemia, Cancer Gene Therapy (2016)

48. Eya1 Expression in Gastric Carcinoma and Its Association With Clinicopathological Characteristics: A Pilot Study, Medical Oncology (2014)

49. Msi1 Overexpression in Diffuse Type of Gastric Cancer, Pathology Research and Practice (2013)

50. Microrna-196A As a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma, Cancer Investigation (2017)

Style	Citing Format
MLA	Dehdashtian E, et al.. "A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients." Gene Reports, vol. 17, no. , 2019, pp. -.
APA	Dehdashtian E, Tabatabaeian H, Ghaedi K, Talebi A, Adami B (2019). A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients. Gene Reports, 17(), -.
Chicago	Dehdashtian E, Tabatabaeian H, Ghaedi K, Talebi A, Adami B. "A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients." Gene Reports 17, no. (2019): -.
Harvard	Dehdashtian E et al. (2019) 'A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients', Gene Reports, 17(), pp. -.
Vancouver	Dehdashtian E, Tabatabaeian H, Ghaedi K, Talebi A, Adami B. A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients. Gene Reports. 2019;17():-.
BibTex	@article{ author = {Dehdashtian E and Tabatabaeian H and Ghaedi K and Talebi A and Adami B}, title = {A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients}, journal = {Gene Reports}, volume = {17}, number = {}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Dehdashtian E AU - Tabatabaeian H AU - Ghaedi K AU - Talebi A AU - Adami B TI - A H. Pylori-Independent Mir-21 Overexpression in Gastric Cancer Patients JO - Gene Reports VL - 17 IS - SP - EP - PY - 2019 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract