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Statins: A New Approach to Combat Temozolomide Chemoresistance in Glioblastoma Publisher Pubmed



Shojaei S1, 2 ; Alizadeh J1 ; Thliveris J1 ; Koleini N3, 4 ; Kardami E1, 3, 4 ; Hatch GM5 ; Xu F5 ; Hombachklonisch S1 ; Klonisch T1 ; Ghavami S1, 6, 7
Authors
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Authors Affiliations
  1. 1. Department of Human Anatomy and Cell Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, R3E0J9, MB, Canada
  2. 2. Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada
  4. 4. Institute of Cardiovascular Sciences, St. Boniface Hospital AlbrechtsenResearch Center, Winnipeg, MB, Canada
  5. 5. Pharmacology and Therapeutics, Max Rady College of Medicine, Rady Faculty of Helath Sciences, University of Manitoba, Winnipeg, MB, Canada
  6. 6. Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, Winnipeg, MB, Canada
  7. 7. Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Fars, Iran

Source: Journal of Investigative Medicine Published:2018


Abstract

Patients with glioblastoma multiforme (GBM) have an average life expectancy of approximately 15 months. Recently, statins have emerged as a potential adjuvant cancer therapy due to their ability to inhibit cell proliferation and induce apoptosis in many types of cancer. The exact mechanisms that mediate the inhibitory actions of statins in cancer cells are largely unknown. The purpose of this proceeding paper is to discuss some of the known anticancer effects of statins, while focusing on GBM therapy that includes adjunct therapy of statins with chemotherapeutic agents. © 2018 American Federation for Medical Research.
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