Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Azithromycin Effect on Helicobacter Pylori Eradication: Double Blind Randomized Clinical Trial Pubmed



Rogha M1 ; Pourmoghaddas Z2 ; Rezaee M1 ; Shirneshan K3 ; Shahi Z4
Authors

Source: Hepato-Gastroenterology Published:2009


Abstract

Background/Aims: To evaluate the efficacy of one-and two-week regimen of quadruple therapy containing azithromycin for Helicobacter pylori infection eradication. Methodology: A total of 84 H. pylori-infected patients, were randomized into three groups: First group (n=31): 6g AzOAB: Azithramycin 500mg twice daily for 6 days and Omeprazole 20mg, Amoxicillin 1g, Bismuth 240mg all twice daily for 2 weeks. Second group (n=28): 3g AzOAB: Azithramycin 500mg twice daily for 3 days and Omeprazole 20mg, Amoxicillin Ig, Bismuth 240mg all twice daily for 1 week. Third group (n=25): 1.5g AzOAB: Azithromycin 250mg twice daily for 3 days and Omeprazole 20mg, Amoxicillin Ig, Bismuth 240mg all twice daily for 1 week. Eradication was defined as a negative urea breath test, four weeks after the end of treatment. Results: The eradication rate in the first, second and third group was 92% (95% CI: 84-99.8%), 88.46% (95% CI: 84.47-84.74%), 80% (95% CI: 79.88-80.11%) respectively, based on per-protocol analysis. There was no significant difference between eradication rates (P=0.44). The frequency of drug side effects in the study groups was respectively 19.23%, 7.6% and 0%. There was no statistically significant difference between the three regimens (P=0.06). However, frequency of drug side effects between 6g AzOAB and 1.5g AzOAB was statistically significant (P=0.02). Conclusions: According to the results of these 3 regimens, it seems that one week quadruple regimens of 3g Azithromycin may be more favorable for H. pylori eradication. © H.G.E. Update Medical Publishing S.A.
Other Related Docs
15. Helicobacter Pylori in Iran: A Systematic Review on the Antibiotic Resistance, Iranian Journal of Basic Medical Sciences (2015)