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Prevalence of Resistance of Helicobacter Pylori Strains to Selected Antibiotics in Isfahan, Iran Publisher



Mirzaei N1 ; Poursina F2 ; Faghri J2 ; Talebi M3 ; Khataminezhad MR1 ; Hasanzadeh A4 ; Ghasemian Safaei H2
Authors
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Authors Affiliations
  1. 1. Department of Biology, Tonekabon branch, Islamic Azad University, Tonekabon, Iran
  2. 2. Department of Microbiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Gastroenterology, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Biostatistics and Epidemiology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Jundishapur Journal of Microbiology Published:2013


Abstract

Background: Helicobacter pylori (H. pylori) is one of the most common infectious diseases in the world. It colonizes about 50-60% of the world's population. The estimated prevalence of H. pylori infection is approximately 65% in Iran. Objectives: The aim of the present study was to investigate the antimicrobial resistance of H. pylori to metronidazole, clarithromycin and amoxicillin. Materials and Methods: A total of 110 biopsy specimens were collected from patients with clinical symptoms of gastrointestinal disorders who were referred to the endoscopy unit at Al-Zahra Hospital, Isfahan, Iran. We investigated the frequency of H. pylori resistance to metronidazole, clarithromycin and amoxicillin among 48 positive isolates of H. pylori from the referred patients. After the culture of biopsy specimens and identification of H. pylori strains, susceptibility tests were done using the E test (epsilometer test) Results: The overall rates of resistance to metronidazole, clarithromycin and amoxicillin were 56.3%, 14.6% and 4.2% respectively. In our study, there was a significant correlation between resistance to metronidazole and gender (P < 0.05) but there was no significant correlation between resistance to amoxicillin and clarithromycin and gender (P < 0.05). Conclusions: Information on antibiotic susceptibility profile plays an important role in empiric antibiotic treatment and management of refractive cases. With regards to this study, using metronidazole in the Isfahan region, can lead to eradication failure in clinical therapies due to having the highest rate of resistance but amoxicillin and clarithromycin are prescribed for first and second lines of treatment against H. pylori. Actually, susceptibility testing of H. pylori isolates in different geographical areas is advised because it aids the selection of optimal therapy regimens. © 2013, Ahvaz Jundishapur University of Medical Sciences; Licensee Kowsar Ltd.
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