Dose–Response Association Between Animal Protein Sources and Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis Publisher Pubmed



Talebi S^{1, 2} ; Ghoreishy SM^{3, 4} ; Ghavami A⁵ ; Sikaroudi MK² ; Nielsen SM^{6, 7} ; Talebi A⁸ ; Mohammadi H² Show Affiliations
Source: Nutrition Reviews Published:2024

Abstract

Context: There are contradictory findings about the relationship between various animal protein sources and the risk of gestational diabetes mellitus (GDM). Objective: The purpose of our study was to understand better the associations between total protein, animal protein, and animal protein sources and the risk of developing GDM. Data Sources: A systematic literature search was conducted in PubMed, Scopus, and Web of Science encompassing the literature up until August 2022. A random-effects model was used to combine the data. For estimating the dose–response curves, a one-stage linear mixed-effects meta-analysis was conducted. Data Extraction: Data related to the association between animal protein consumption and the risk of GDM in the general population was extracted from prospective cohort studies. Data Analysis: It was determined that 17 prospective cohort studies with a total of 49 120 participants met the eligibility criteria. It was concluded with high certainty of evidence that there was a significant association between dietary animal protein intake and GDM risk (1.94, 95% CI 1.42 to 2.65, n ¼ 6). Moreover, a higher intake of total protein, total meat, and red meat was positively and significantly associated with an increased risk of GDM. The pooled relative risks of GDM were 1.50 (95% CI: 1.16, 1.94; n ¼ 3) for a 30 g/d increment in processed meat, 1.68 (95% CI: 1.25, 2.24; n ¼ 2) and 1.94 (95% CI: 1.41, 2.67; n ¼ 4) for a 100 g/d increment in total and red meat, and 1.21 (95% CI: 1.10, 1.33; n ¼ 4) and 1.32 (95% CI: 1.15, 1.52; n ¼ 3) for a 5% increment in total protein and animal protein, respectively. GDM had a positive linear association with total protein, animal protein, total meat consumption, and red meat consumption, based on non-linear dose–response analysis. Conclusion: Overall, consuming more animal protein–rich foods can increase the risk of GDM. The results from the current study need to be validated by other, well-designed prospective studies. © The Author(s) 2023. Published by Oxford University Press on behalf of the International Life Sciences Institute.