Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Potential of Renin-Angiotensin System Inhibition to Improve Metabolic Bone Disorders Publisher



Momenzadeh M1 ; Khosravian M2 ; Lakkakula BVKS3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Institute of Biology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
  3. 3. Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India

Source: Journal of Nephropharmacology Published:2021


Abstract

Metabolic bone disorder is an abnormality of bones indicated by reduced bone mass and high risk of fractures. Several lines of evidence have demonstrated that the local bone tissue reninangiotensin system (RAS) is directly involved in bone metabolism and influences the bone health. This review aimed to assess the role of RAS in bone metabolism and comparative effectiveness of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) in reducing the bone fractures. In summary, the clinical trials, in vivo studies, and functional-pharmacological experiments suggested that the RAS regulates bone marrow metabolism and influences the bone health. Hence, it warrants further investigation on the role of ACEIs and ARBs in reducing risk fractures. © 2021 The Author(s); Published by Published by Society of Diabetic Nephropathy Prevention.
Related Docs
1. Effects of Vasodepressor Vs. Vasopressor Arms of Renin Angiotensin System on Renal Hemodynamic Regulation in Renal Ischemia-Reperfusion Injury; Sex Difference, Journal of Isfahan Medical School (2022)
2. Sex Difference in Masr Expression and Functions in the Renal System, JRAAS - Journal of the Renin-Angiotensin-Aldosterone System (2022)
3. Assessment of Enalapril Effect on Inducing Anemia in Non-Azotemic Diabetic Patients, Journal of Research in Medical Sciences (2005)
4. View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury, JRAAS - Journal of the Renin-Angiotensin-Aldosterone System (2022)
Experts (# of related papers)
View all Related Experts
Mehdi Nematbakhsh (3)
Shiva Seirafian (1)