Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Dna Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-Wide Consortium Meta-Analysis Publisher Pubmed



Joubert BR1 ; Felix JF2, 3, 4 ; Yousefi P5 ; Bakulski KM6 ; Just AC7 ; Breton C8 ; Reese SE1 ; Markunas CA1, 9 ; Richmond RC10 ; Xu CJ11, 12, 13 ; Kupers LK14 ; Oh SS15 ; Hoyo C16 ; Gruzieva O17 Show All Authors
Authors
  1. Joubert BR1
  2. Felix JF2, 3, 4
  3. Yousefi P5
  4. Bakulski KM6
  5. Just AC7
  6. Breton C8
  7. Reese SE1
  8. Markunas CA1, 9
  9. Richmond RC10
  10. Xu CJ11, 12, 13
  11. Kupers LK14
  12. Oh SS15
  13. Hoyo C16
  14. Gruzieva O17
  15. Soderhall C18
  16. Salas LA19, 20, 21
  17. Baiz N22
  18. Zhang H23
  19. Lepeule J24
  20. Ruiz C19, 20, 21
  21. Ligthart S2
  22. Wang T1
  23. Taylor JA1
  24. Duijts L2, 4, 25, 26
  25. Sharp GC10
  26. Jankipersadsing SA11, 12
  27. Nilsen RM27
  28. Vaez A14, 28
  29. Fallin MD6
  30. Hu D15
  31. Litonjua AA29
  32. Fuemmeler BF30
  33. Huen K5
  34. Kere J18
  35. Kull I17
  36. Munthekaas MC31
  37. Gehring U32
  38. Bustamante M19, 20, 21, 33
  39. Saurelcoubizolles MJ34
  40. Quraishi BM23
  41. Ren J8
  42. Tost J35
  43. Gonzalez JR19, 20, 21
  44. Peters MJ36
  45. Haberg SE37
  46. Xu Z1
  47. Van Meurs JB36
  48. Gaunt TR10
  49. Kerkhof M13
  50. Corpeleijn E14
  51. Feinberg AP38
  52. Eng C15
  53. Baccarelli AA39
  54. Benjamin Neelon SE6
  55. Bradman A5
  56. Merid SK17
  57. Bergstrom A17
  58. Herceg Z40
  59. Hernandezvargas H40
  60. Brunekreef B32, 41
  61. Pinart M19, 20, 21, 42
  62. Heude B43
  63. Ewart S44
  64. Yao J8
  65. Lemonnier N45
  66. Franco OH2
  67. Wu MC46
  68. Hofman A2, 47
  69. Mcardle W48
  70. Van Der Vlies P11
  71. Falahi F14
  72. Gillman MW49
  73. Barcellos LF5
  74. Kumar A17, 50, 51
  75. Wickman M17, 52
  76. Guerra S19
  77. Charles MA43
  78. Holloway J53, 54
  79. Auffray C45
  80. Tiemeier HW4
  81. Smith GD10
  82. Postma D12, 13
  83. Hivert MF49
  84. Eskenazi B5
  85. Vrijheid M19, 20, 21
  86. Arshad H53
  87. Anto JM19, 20, 21, 42
  88. Dehghan A2
  89. Karmaus W23
  90. Annesimaesano I22
  91. Sunyer J19, 20, 21, 42
  92. Ghantous A40
  93. Pershagen G17
  94. Holland N5
  95. Murphy SK55
  96. Demeo DL29
  97. Burchard EG15, 56
  98. Laddacosta C6
  99. Snieder H14
  100. Nystad W37
  101. Koppelman GH13, 57
  102. Relton CL10
  103. Jaddoe VWV2, 3, 4
  104. Wilcox A1
  105. Melen E17, 52
  106. London SJ1
Show Affiliations
Authors Affiliations
  1. 1. National Institute of Environmental Health Sciences, NIH, U.S. Department of Health and Human Services, Research Triangle Park, 27709, NC, United States
  2. 2. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, Netherlands
  3. 3. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, Netherlands
  4. 4. Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, Netherlands
  5. 5. Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California Berkeley, Berkeley, 94720-7360, CA, United States
  6. 6. Bloomberg School of Public Health, Johns Hopkins University, Baltimore, 21205, MD, United States
  7. 7. Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, 10029, NY, United States
  8. 8. University of Southern California, Los Angeles, 90032, CA, United States
  9. 9. Duke Molecular Physiology Institute, Duke University Medical Center, Durham, 27710, NC, United States
  10. 10. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom
  11. 11. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands
  12. 12. Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands
  13. 13. GRIAC Research Institute Groningen, University of Groningen, University Medical Center, Groningen, 9700 RB, Netherlands
  14. 14. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands
  15. 15. Department of Medicine, University of California San Francisco, San Francisco, 94143-2911, CA, United States
  16. 16. Department of Biological Sciences and Center for Human Health and the Environment, North Carolina State University, Raleigh, 2769 5-7633, NC, United States
  17. 17. Institute of Environmental Medicine, Karolinska Institutet, Stockholm, 171 77, Sweden
  18. 18. Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, 141 83, Sweden
  19. 19. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, 08003, Spain
  20. 20. CIBER Epidemiologia y Salud Publica (CIBERESP), Barcelona, 08003, Spain
  21. 21. Universitat Pompeu Fabra (UPF), Barcelona, 08003, Spain
  22. 22. Sorbonne Universites, UPMC Univ Paris 06, INSERM, Pierre Louis Institute of Epidemiology and Public Health (IPLESP UMRS 1136), Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Saint-Antoine Medical School, Paris, F75012, France
  23. 23. Division of Epidemiology Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, 38152, TN, United States
  24. 24. Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Institut Albert Bonniot, Institut National de la Sante et de le Recherche Medicale, University of Grenoble Alpes, Centre Hospitalier Universitaire de Grenoble, Grenoble, F-38000, France
  25. 25. Division of Neonatology, Department of Pediatrics Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, Netherlands
  26. 26. Division of Respiratory Medicine, Department of Pediatrics Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, Netherlands
  27. 27. Department of Global Public Health and Primary Care, University of Bergen, Bergen Norway, 5018, Norway
  28. 28. School of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  29. 29. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, 02115, MA, United States
  30. 30. Department of Community and Family Medicine, Duke University School of Medicine, Durham, 27710, NC, United States
  31. 31. Department of Pediatrics, Oslo University Hospital, Oslo 424, Norway
  32. 32. Institute for Risk Assessment Sciences, Utrecht University, Utrecht, 3508 TD, Netherlands
  33. 33. Center for Genomic Regulation (CRG), Barcelona, 08003, Spain
  34. 34. INSERM, Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Paris, 75654, France
  35. 35. Laboratory for Epigenetics and Environment, Centre National de Genotypage, CEA-Institut de Genomique, Evry, 91000, France
  36. 36. Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, 3000 CA, Netherlands
  37. 37. Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, 0403, Norway
  38. 38. Johns Hopkins University School of Medicine, Baltimore, 21205, MD, United States
  39. 39. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, United States
  40. 40. Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, 69008, France
  41. 41. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3508 TD, Netherlands
  42. 42. Hospital Del Mar Medical Research Institute (IMIM), Barcelona, 08003, Spain
  43. 43. INSERM, UMR 1153, Early Origin of the Child's Health and Development (ORCHAD) Team, Centre de Recherche Epidemiologie et Statistique Sorbonne Paris Cite (CRESS), Universite Paris Descartes, Villejuif, 94807, France
  44. 44. Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, 48824, MI, United States
  45. 45. Ctr. Natl. de la Recherche Scientifique-Ecole Normale Superieure de Lyon-Universite Claude Bernard, Universite de Lyon, European Institute for Systems Biology and Medicine, Lyon, 69007, France
  46. 46. Fred Hutchinson Cancer Research Center, Seattle, 98109, WA, United States
  47. 47. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 02115, MA, United States
  48. 48. School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, United Kingdom
  49. 49. Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, 02215, MA, United States
  50. 50. Department of Public Health Epidemiology, Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, Basel, 4051, Switzerland
  51. 51. University of Basel, Basel, 4001, Switzerland
  52. 52. Sachs' Children's Hospital and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm Sweden, 171 77, Sweden
  53. 53. Faculty of Medicine, Clinical and Experimental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
  54. 54. Faculty of Medicine, Human Development and Health, University of Southampton, Southampton, SO16 6Y, United Kingdom
  55. 55. Departments of Obstetrics and Gynecology and Pathology, Duke University School of Medicine, Durham, 27710, NC, United States
  56. 56. Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, 94143-2911, CA, United States
  57. 57. Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, Netherlands

Source: American Journal of Human Genetics Published:2016


Abstract

Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in either newborns or adults. Several genes are relevant to diseases that can be caused by maternal smoking (e.g., orofacial clefts and asthma) or adult smoking (e.g., certain cancers). A number of differentially methylated CpGs were associated with gene expression. We observed enrichment in pathways and processes critical to development. In older children (5 cohorts, n = 3,187), 100% of CpGs gave at least nominal levels of significance, far more than expected by chance (p value < 2.2 × 10-16). Results were robust to different normalization methods used across studies and cell type adjustment. In this large scale meta-analysis of methylation data, we identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure. © 2016 The American Society of Human Genetics. All rights reserved.
Other Related Docs
13. Alterations of Epigenetic Landscape in Down Syndrome Carrying Pregnancies: A Systematic Review of Case-Control Studies, European Journal of Obstetrics and Gynecology and Reproductive Biology (2021)
14. Prenatal Nutrition Exposure Leading to Adult Obesity, Diabetes, and Hypertension, Nutrigenomics and Nutraceuticals: Clinical Relevance and Disease Prevention (2017)
15. Epigenetics and Common Non Communicable Disease, Advances in Experimental Medicine and Biology (2019)
18. Gene-Environment Interaction in Origins of Chronic Non-Communicable Disease, Gene-Environment Interactions and Human Diseases (2016)