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Genome-Wide Analysis Identifies 12 Loci Influencing Human Reproductive Behavior Publisher Pubmed



Barban N1 ; Jansen R2 ; De Vlaming R3, 4, 5 ; Vaez A6, 7 ; Mandemakers JJ8 ; Tropf FC1 ; Shen X9, 10, 11 ; Wilson JF10, 11 ; Chasman DI12 ; Nolte IM6 ; Tragante V13 ; Van Der Laan SW14 ; Perry JRB15 ; Kong A16, 17 Show All Authors
Authors
  1. Barban N1
  2. Jansen R2
  3. De Vlaming R3, 4, 5
  4. Vaez A6, 7
  5. Mandemakers JJ8
  6. Tropf FC1
  7. Shen X9, 10, 11
  8. Wilson JF10, 11
  9. Chasman DI12
  10. Nolte IM6
  11. Tragante V13
  12. Van Der Laan SW14
  13. Perry JRB15
  14. Kong A16, 17
  15. Ahluwalia TS18, 19, 20
  16. Albrecht E21
  17. Yergesarmstrong L22
  18. Atzmon G23, 24, 25
  19. Auro K26, 27
  20. Ayers K28
  21. Bakshi A29
  22. Benavraham D24
  23. Berger K30
  24. Bergman A31
  25. Bertram L32, 33
  26. Bielak LF34
  27. Bjornsdottir G16
  28. Bonder MJ35
  29. Broer L36
  30. Bui M37
  31. Barbieri C38
  32. Cavadino A39, 40
  33. Chavarro JE41, 42, 43
  34. Turman C43
  35. Concas MP44
  36. Cordell HJ28
  37. Davies G45, 46
  38. Eibich P47
  39. Eriksson N48
  40. Esko T49, 50
  41. Eriksson J51
  42. Falahi F6
  43. Felix JF4, 52, 53
  44. Fontana MA54
  45. Franke L35
  46. Gandin I55
  47. Gaskins AJ41
  48. Gieger C56, 57
  49. Gunderson EP58
  50. Guo X59
  51. Hayward C10
  52. He C60
  53. Hofer E61, 62
  54. Huang H43
  55. Joshi PK11
  56. Kanoni S63
  57. Karlsson R9
  58. Kiechl S64
  59. Kifley A65
  60. Kluttig A66
  61. Kraft P43, 67
  62. Lagou V68, 69, 70
  63. Lecoeur C71
  64. Lahti J72, 73, 74
  65. Ligao R75
  66. Lind PA76
  67. Liu T77
  68. Makalic E37
  69. Mamasoula C28
  70. Matteson L78
  71. Mbarek H79, 80
  72. Mcardle PF22
  73. Mcmahon G81
  74. Meddens SFW5, 82
  75. Mihailov E49
  76. Miller M83
  77. Missmer SA43, 84
  78. Monnereau C4, 52, 53
  79. Van Der Most PJ6
  80. Myhre R85
  81. Nalls MA86
  82. Nutile T87
  83. Kalafati IP88
  84. Porcu E89, 90
  85. Prokopenko I91, 92, 93
  86. Rajan KB94
  87. Richedwards J42, 43, 95
  88. Rietveld CA3, 4, 5
  89. Robino A96
  90. Rose LM12
  91. Rueedi R97, 98
  92. Ryan KA22
  93. Saba Y99
  94. Schmidt D37
  95. Smith JA34
  96. Stolk L36
  97. Streeten E22
  98. Tonjes A100
  99. Thorleifsson G17
  100. Ulivi S96
  101. Wedenoja J101
  102. Wellmann J30
  103. Willeit P64, 102, 103
  104. Yao J59
  105. Yengo L71, 104
  106. Zhao JH15
  107. Zhao W34
  108. Zhernakova DV35
  109. Amin N4
  110. Andrews H105
  111. Balkau B71
  112. Barzilai N23
  113. Bergmann S97, 98
  114. Biino G106
  115. Bisgaard H20
  116. Bonnelykke K20
  117. Boomsma DI79, 80
  118. Buring JE12
  119. Campbell H11
  120. Cappellani S96
  121. Ciullo M87, 107
  122. Cox SR45, 46
  123. Cucca F89, 90
  124. Toniolo D38
  125. Daveysmith G108
  126. Deary IJ45, 46
  127. Dedoussis G88
  128. Deloukas P63, 109
  129. Van Duijn CM4
  130. De Geus EJC79, 80
  131. Eriksson JG74, 110, 111, 112, 113
  132. Evans DA94
  133. Faul JD114
  134. Sala CF38
  135. Froguel P71
  136. Gasparini P55, 115
  137. Girotto G55, 115
  138. Grabe HJ116
  139. Greiser KH117
  140. Groenen PJF5, 118
  141. De Haan HG75
  142. Haerting J66
  143. Harris TB119
  144. Heath AC120
  145. Heikkila K27
  146. Hofman A4, 5, 43
  147. Homuth G121
  148. Holliday EG122, 123
  149. Hopper J37
  150. Hypponen E39, 124, 125
  151. Jacobsson B85, 126
  152. Jaddoe VWV4, 52, 53
  153. Johannesson M127
  154. Jugessur A85
  155. Kahonen M128
  156. Kajantie E129, 130, 131
  157. Kardia SLR34
  158. Keavney B28, 132
  159. Kolcic I133
  160. Koponen P134
  161. Kovacs P135
  162. Kronenberg F136
  163. Kutalik Z98, 137
  164. La Bianca M96
  165. Lachance G138
  166. Iacono WG83
  167. Lai S89
  168. Lehtimaki T139
  169. Liewald DC45
  170. Lindgren CM92, 93, 140, 141
  171. Liu Y142
  172. Luben R143
  173. Lucht M110
  174. Luoto R144
  175. Magnus P85
  176. Magnusson P9
  177. Martin NG76
  178. Mcgue M83, 145
  179. Mcquillan R11
  180. Medland SE76
  181. Meisinger C57, 146
  182. Mellstrom D51
  183. Metspalu A49, 147
  184. Traglia M38
  185. Milani L49
  186. Mitchell P65
  187. Montgomery GW120, 148
  188. Mookkanamori D75, 149, 150
  189. De Mutsert R75
  190. Nohr EA151
  191. Ohlsson C51
  192. Olsen J152
  193. Ong KK15
  194. Paternoster L108
  195. Pattie A46
  196. Penninx BWJH2, 80
  197. Perola M26, 27, 49
  198. Peyser PA34
  199. Pirastu M44
  200. Polasek O133
  201. Power C39
  202. Kaprio J26, 27, 101
  203. Raffel LJ153
  204. Raikkonen K72
  205. Raitakari O154
  206. Ridker PM12
  207. Ring SM108
  208. Roll K59
  209. Rudan I11
  210. Ruggiero D87
  211. Rujescu D155
  212. Salomaa V26
  213. Schlessinger D156
  214. Schmidt H99
  215. Schmidt R61
  216. Schupf N157
  217. Smit J2, 80
  218. Sorice R87, 107
  219. Spector TD138
  220. Starr JM45, 158
  221. Stockl D157
  222. Strauch K21, 159
  223. Stumvoll M100, 135
  224. Swertz MA35
  225. Thorsteinsdottir U17, 160
  226. Roy Thurik A3, 5, 161
  227. Timpson NJ108
  228. Tung JY48
  229. Uitterlinden AG3, 5, 36
  230. Vaccargiu S44
  231. Viikari J162
  232. Vitart V10
  233. Volzke H163
  234. Vollenweider P164
  235. Vuckovic D55, 115
  236. Waage J20
  237. Wagner GG165
  238. Wang JJ65
  239. Wareham NJ15
  240. Weir DR114
  241. Willemsen G79, 80
  242. Willeit J64
  243. Wright AF10
  244. Zondervan KT166, 167
  245. Stefansson K17, 160
  246. Krueger RF83
  247. Lee JJ83
  248. Benjamin DJ54, 168
  249. Cesarini D169, 170
  250. Koellinger PD3, 5, 82
  251. Den Hoed M171
  252. Snieder H6
  253. Mills MC1
Show Affiliations
Authors Affiliations
  1. 1. Department of Sociology and Nuffield College, University of Oxford, Oxford, United Kingdom
  2. 2. Department of Psychiatry, VU University Medical Center, Amsterdam, Netherlands
  3. 3. Department of Applied Economics, Erasmus School of Economics, Rotterdam, Netherlands
  4. 4. Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
  5. 5. Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, Netherlands
  6. 6. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
  7. 7. Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. Sociology of Consumption and Households, Wageningen University Research, Wageningen, Netherlands
  9. 9. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  10. 10. MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
  11. 11. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom
  12. 12. Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  13. 13. Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands
  14. 14. Laboratory of Experimental Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands
  15. 15. MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom
  16. 16. School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland
  17. 17. DeCODE Genetics/Amgen, Inc., Reykjavik, Iceland
  18. 18. Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  19. 19. Steno Diabetes Center, Gentofte, Denmark
  20. 20. COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
  21. 21. Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg, Germany
  22. 22. Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, MD, United States
  23. 23. Department of Medicine, Institute for Aging Research, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY, United States
  24. 24. Department of Genetics, Institute for Aging Research, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY, United States
  25. 25. Department of Natural Science, University of Haifa, Haifa, Israel
  26. 26. Department of Health, National Institute for Health and Welfare, Helsinki, Finland
  27. 27. Institute for Molecular Medicine (FIMM), University of Helsinki, Helsinki, Finland
  28. 28. Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, United Kingdom
  29. 29. Queensland Brain Institute, University of Queensland, Brisbane, QLD, Australia
  30. 30. Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany
  31. 31. Department of Systems and Computational Biology, Department of Pathology, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY, United States
  32. 32. Lubeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and of Integrative and Experimental Genomics, University of Lubeck, Lubeck, Germany
  33. 33. School of Public Health, Faculty of Medicine, Imperial College, London, United Kingdom
  34. 34. Department of Epidemiology, University of Michigan, Ann Arbor, MI, United States
  35. 35. Department of Genetics, Genomics Coordination Center, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
  36. 36. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands
  37. 37. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia
  38. 38. Division of Genetics and Cell Biology, San Raffaele Research Institute, Milan, Italy
  39. 39. Population, Policy and Practice, UCL Institute of Child Health, London, United Kingdom
  40. 40. Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventative Medicine, Queen Mary University of London, London, United Kingdom
  41. 41. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  42. 42. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  43. 43. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  44. 44. Institute of Genetic and Biomedical Research, National Research Council, UOS of Sassari, Sassari, Italy
  45. 45. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
  46. 46. Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
  47. 47. Health Economics Research Centre, University of Oxford, Oxford, United Kingdom
  48. 48. 23andMe, Inc., Mountain View, CA, United States
  49. 49. Estonian Genome Center, University of Tartu, Tartu, Estonia
  50. 50. Broad Institute of mit and Harvard, Cambridge, MA, United States
  51. 51. Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  52. 52. Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
  53. 53. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
  54. 54. Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States
  55. 55. Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy
  56. 56. Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg, Germany
  57. 57. Institute of Epidemiology II, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg, Germany
  58. 58. Cardiovascular and Metabolic Conditions Section, Division of Research, Kaiser Permanente Northern California, Oakland, CA, United States
  59. 59. Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, United States
  60. 60. Department of Epidemiology, Indiana University, Richard M. Fairbanks School of Public Health, Indianapolis, IN, United States
  61. 61. Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria
  62. 62. Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria
  63. 63. William Harvey Research Institute, Barts, London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
  64. 64. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
  65. 65. Centre for Vision Research, Department of Ophthalmology, Westmead Institute for Medical Research, University of Sydney, Westmead, NSW, Australia
  66. 66. Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
  67. 67. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States
  68. 68. Department of Neurosciences, KU Leuven, Leuven, Belgium
  69. 69. Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium
  70. 70. Translational Immunology Laboratory, VIB, Leuven, Belgium
  71. 71. University of Lille, CNRS, Institut Pasteur of Lille, Lille, France
  72. 72. Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland
  73. 73. Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland
  74. 74. Folkhalsan Research Centre, Helsinki, Finland
  75. 75. Department of Clinical Epidemiology, Leiden University, Medical Center, Leiden, Netherlands
  76. 76. Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Herston Brisbane, QLD, Australia
  77. 77. Center for Lifespan Psychology, Max Planck Institute for Human Development, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
  78. 78. Minnesota Center for Twin and Family Research, Department of Psychology, University of Minnesota, Minneapolis, MN, United States
  79. 79. Department of Biological Psychology, VU University, Amsterdam, Netherlands
  80. 80. EMGO+ Institute for Health and Care Research, Amsterdam, Netherlands
  81. 81. School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
  82. 82. Complex Trait Genetics, VU University, Amsterdam, Netherlands
  83. 83. Department of Psychology, University of Minnesota, Minneapolis, MN, United States
  84. 84. Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  85. 85. Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Institute of Public Health, Oslo, Norway
  86. 86. Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, MD, United States
  87. 87. Institute of Genetics and Biophysics A. Buzzati-Traverso, CNR, Naples, Italy
  88. 88. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece
  89. 89. Istituto di Ricerca Genetica e Biomedica, CMR, Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy
  90. 90. Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy
  91. 91. Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, United Kingdom
  92. 92. Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
  93. 93. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom
  94. 94. Rush University Medical Center, Chicago, IL, United States
  95. 95. Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
  96. 96. Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
  97. 97. Department of Computational Biology, University of Lausanne, Lausanne, Switzerland
  98. 98. Swiss Institute of Bioinformatics, Lausanne, Switzerland
  99. 99. Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria
  100. 100. Department of Medicine, University of Leipzig, Leipzig, Germany
  101. 101. Department of Public Health, University of Helsinki, Helsinki, Finland
  102. 102. King's British Heart Foundation Centre, King's College London, London, United Kingdom
  103. 103. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
  104. 104. Centre for Neurogenetics and Statistical Genomics, University of Queensland, Brisbane, QLD, Australia
  105. 105. Data Coordinating Center, New York State Psychiatric Institute, New York, NY, United States
  106. 106. Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy
  107. 107. IRCCS Neuromed, Pozzilli, Isernia, Italy
  108. 108. MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom
  109. 109. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia
  110. 110. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
  111. 111. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
  112. 112. Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland
  113. 113. Vasa Central Hospital, Vasa, Finland
  114. 114. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, United States
  115. 115. Division of Experimental Genetics, Sidra, Doha, Qatar
  116. 116. Department of Psychiatry, University Medicine Greifswald, Greifswald, Germany
  117. 117. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
  118. 118. Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, Netherlands
  119. 119. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, United States
  120. 120. Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
  121. 121. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
  122. 122. School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia
  123. 123. Hunter Medical Research Institute, Newcastle, NSW, Australia
  124. 124. Centre for Population Health Research, Sansom Institute of Health Research, School of Health Sciences, University of South Australia, Adelaide, SA, Australia
  125. 125. South Australian Health and Medical Research Institute, Adelaide, SA, Australia
  126. 126. Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden
  127. 127. Department of Economics, Stockholm School of Economics, Stockholm, Sweden
  128. 128. Department of Clinical Physiology, University of Tampere, Tampere University Hospital, Tampere, Finland
  129. 129. Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
  130. 130. Children's Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
  131. 131. Department of Obstetrics and Gynecology, MRC Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland
  132. 132. Institute of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom
  133. 133. Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia
  134. 134. Health Monitoring Unit, National Institute for Health and Welfare, Helsinki, Finland
  135. 135. IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany
  136. 136. Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria
  137. 137. Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  138. 138. Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom
  139. 139. Department of Clinical Chemistry, Fimlab Laboratories, School of Medicine, University of Tampere, Tampere, Finland
  140. 140. NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom
  141. 141. Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, United Kingdom
  142. 142. Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, United States
  143. 143. Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
  144. 144. UKK Institute for Health Promotion, Tampere, Finland
  145. 145. Danish Aging Research Center and Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
  146. 146. MONICA/KORA Myocardial Infarction Registry, Central Hospital of Augsburg, Augsburg, Germany
  147. 147. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
  148. 148. Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
  149. 149. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands
  150. 150. Department of BESC, Epidemiology Section, King Faisal Specialist Hospital, Research Centre, Riyadh, Saudi Arabia
  151. 151. Research Unit for Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  152. 152. Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark
  153. 153. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States
  154. 154. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
  155. 155. Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
  156. 156. Laboratory of Genetics, National Institute on Aging, Baltimore, MD, United States
  157. 157. Department of Epidemiology and Psychiatry, Columbia University, Medical Center, New York, NY, United States
  158. 158. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom
  159. 159. Institute of Medical Informatics, Biometry and Epidemiology, Department of Genetic Epidemiology, Ludwig Maximilians Universitat, Munich, Germany
  160. 160. Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  161. 161. Montpellier Business School, Montpellier, France
  162. 162. Department of Medicine, University of Turku, Division of Medicine, Turku University Hospital, Turku, Finland
  163. 163. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
  164. 164. Department of Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland
  165. 165. German Socio-Economic Panel Study (SOEP), Max Planck Institute for Human Development, Berlin University of Technology (TUB), Berlin, Germany
  166. 166. Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
  167. 167. Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, United Kingdom
  168. 168. National Bureau of Economic Research, Cambridge, MA, United States
  169. 169. Department of Economics, New York University, New York, NY, United States
  170. 170. Research Institute for Industrial Economics, Stockholm, Sweden
  171. 171. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

Source: Nature Genetics Published:2016


Abstract

The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.
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