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Pharmacotherapeutic Potential of Pomegranate in Age-Related Neurological Disorders Publisher



Emami Kazemabad MJ1 ; Asgari Toni S2 ; Tizro N3 ; Dadkhah PA4 ; Amani H5 ; Akhavan Rezayat S6 ; Sheikh Z7 ; Mohammadi M8 ; Alijanzadeh D2 ; Alimohammadi F9 ; Shahrokhi M10 ; Erabi G11 ; Noroozi M12 ; Karimi MA13 Show All Authors
Authors
  1. Emami Kazemabad MJ1
  2. Asgari Toni S2
  3. Tizro N3
  4. Dadkhah PA4
  5. Amani H5
  6. Akhavan Rezayat S6
  7. Sheikh Z7
  8. Mohammadi M8
  9. Alijanzadeh D2
  10. Alimohammadi F9
  11. Shahrokhi M10
  12. Erabi G11
  13. Noroozi M12
  14. Karimi MA13
  15. Honari S5
  16. Deravi N2
Show Affiliations
Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Qom University of Medical Sciences, Qom, Iran
  2. 2. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  4. 4. Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  6. 6. Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran
  7. 7. Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran
  8. 8. Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  9. 9. Student Research Committee, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  10. 10. School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  11. 11. Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran
  12. 12. Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran
  13. 13. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Frontiers in Aging Neuroscience Published:2022


Abstract

Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD] and Parkinson's disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it. Pomegranate (Punica granatum L.) is one of the polyphenol-rich fruits that is widely mentioned in medical folklore. Pomegranate is commonly used to treat common disorders such as diarrhea, abdominal pain, wound healing, bleeding, dysentery, acidosis, microbial infections, infectious and noninfectious respiratory diseases, and neurological disorders. In the current review article, we aimed to summarize the data on the pharmacotherapeutic potentials of pomegranate in ANDs. Copyright © 2022 Emami Kazemabad, Asgari Toni, Tizro, Dadkhah, Amani, Akhavan Rezayat, Sheikh, Mohammadi, Alijanzadeh, Alimohammadi, Shahrokhi, Erabi, Noroozi, Karimi, Honari and Deravi.
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