Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Pulmonary Delivery of Docetaxel and Celecoxib by Plga Porous Microparticles for Their Synergistic Effects Against Lung Cancer Publisher Pubmed



Ziaei E1 ; Emami J1 ; Rezazadeh M1 ; Kazemi M2, 3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  3. 3. Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Anti-Cancer Agents in Medicinal Chemistry Published:2022


Abstract

Background: Using a combination of chemotherapeutic agents with novel drug delivery platforms to enhance the anticancer efficacy of the drug and minimizing the side effects, is imperative to lung cancer treatments. Objective: The aim of the present study was to develop, characterize, and optimize porous poly (D, L-lactic-co-glycolic acid) (PLGA) microparticles for simultaneous delivery of docetaxel (DTX) and celecoxib (CXB) through the pulmonary route for lung cancer. Methods: Drug-loaded porous microparticles were prepared by an emulsion solvent evaporation method. The impact of various processing and formulation variables including PLGA amount, dichloromethane volume, homogenization speed, polyvinyl alcohol volume, and concentration, was assessed based on entrapment efficiency, mean release time, particle size, mass median aerodynamic diameter, fine particle fraction, and geometric standard deviation using a two-level factorial design. An optimized formulation was prepared and evaluated in terms of size and morphology using a scanning electron microscope. Results: FTIR, DSC, and XRD analyses confirmed drug entrapment and revealed no drug-polymer chemical interaction. Cytotoxicity of DTX along with CXB against A549 cells was significantly enhanced compared to DTX and CXB alone and the combination of DTX and CXB showed the greatest synergistic effect at a 1/500 ratio. Conclusion: In conclusion, the results of the present study suggest that encapsulation of DTX and CXB in porous PLGA microspheres with desirable features is feasible and their pulmonary co-administration would be a promising strategy for the effective and less toxic treatment of various lung cancers. © 2022 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Formulation and Optimization of Celecoxib-Loaded Plga Nanoparticles by the Taguchi Design and Their in Vitro Cytotoxicity for Lung Cancer Therapy, Pharmaceutical Development and Technology (2015)
2. Simultaneous Determination of Docetaxel and Celecoxib in Porous Microparticles and Rat Plasma by Liquid-Liquid Extraction and Hplc With Uv Detection: In Vitro and in Vivo Validation and Application, Journal of Pharmacy and Pharmaceutical Sciences (2020)
3. Preparation and Characterization of Spray-Dried Inhalable Powders Containing Polymeric Micelles for Pulmonary Delivery of Paclitaxel in Lung Cancer, Journal of Pharmacy and Pharmaceutical Sciences (2018)
4. Particle Size Design of Plga Microspheres for Potential Pulmonary Drug Delivery Using Response Surface Methodology, Journal of Microencapsulation (2009)
5. Preparation and Characterization of Dry Powder Containing Sunitinib Loaded Phbv Nanoparticles for Enhanced Pulmonary Delivery, Journal of Drug Delivery Science and Technology (2020)
6. Evaluation of Thermosensitive Chitosan Hydrogel Containing Gefitinib Loaded Cellulose Acetate Butyrate Nanoparticles in a Subcutaneous Breast Cancer Model, International Journal of Pharmaceutics (2022)
7. Development of Dry Powder Inhaler Containing Tadalafil-Loaded Plga Nanoparticles, Research in Pharmaceutical Sciences (2017)
8. Synthesis, in Vitro Characterization, and Anti-Tumor Effects of Novel Polystyrene-Poly(Amide-Ether-Ester-Imide) Co-Polymeric Micelles for Delivery of Docetaxel in Breast Cancer in Balb/C Mice, Drug Development and Industrial Pharmacy (2018)
Experts (# of related papers)
View all Related Experts
Jaleh Varshosaz (65)
Mohsen Minaiyan (24)
Other Related Docs
9. Carboxymethyl Cellulose-Based Wafer Enriched With Resveratrol-Loaded Nanoparticles for Enhanced Wound Healing, Drug Delivery and Translational Research (2020)
10. Pulmonary Delivery of Triptorelin Loaded in Pluronic Based Nanomicelles in Rat Model, Current Drug Delivery (2018)
11. Preparation and Evaluation of Inhalable Dry Powder Containing Glucosamine-Conjugated Gefitinib Slns for Lung Cancer Therapy, Drug Development and Industrial Pharmacy (2020)
12. Biocompatible Nanocomposite Scaffolds Based on Carrageenan Incorporating Hydroxyapatite and Hesperidin Loaded Nanoparticles for Bone Tissue Regeneration, Polymers for Advanced Technologies (2024)
13. Lipid Nanocapsules for Imatinib Delivery: Design, Optimization and Evaluation of Anticancer Activity Against Melanoma Cell Line, Iranian Journal of Pharmaceutical Research (2019)
14. Fabrication and Characterization of Injectable Thermosensitive Hydrogel Containing Dipyridamole Loaded Polycaprolactone Nanoparticles for Bone Tissue Engineering, Journal of Drug Delivery Science and Technology (2021)
15. Targeted Nanostructured Lipid Carriers for Delivery of Paclitaxel to Cancer Cells: Preparation, Characterization, and Cell Toxicity, Current Drug Delivery (2017)
16. Formulation and Characterization of Cellulose Acetate Butyrate Nanoparticles Loaded With Nevirapine for Hiv Treatment, Journal of Drug Delivery Science and Technology (2018)
17. The Effect of Process Parameters on the Size and Morphology of Poly(D, L-Lactide-Co-Glycolide) Micro/Nanoparticles Prepared by an Oil in Oil Emulsion/Solvent Evaporation Technique, Journal of Applied Polymer Science (2010)
18. Fabrication of Polymeric Nanoparticles of Poly(Ethylene-Co-Vinyl Acetate) Coated With Chitosan for Pulmonary Delivery of Carvedilol, Journal of Applied Polymer Science (2014)
19. Fabrication of Poly Hydroxybutyrate-Polyethylene Glycol-Folic Acid Nanoparticles Loaded by Paclitaxel, Current Drug Delivery (2016)
20. Preparation and Characterization of a Sustained Release Buccoadhesive System for Delivery of Terbutaline Sulfate, Research in Pharmaceutical Sciences (2013)
21. Preparation and Characterization of Solid Dispersions of Celecoxib Obtained by Spray-Drying Ethanolic Suspensions Containing Pvp-K30 or Isomalt, Journal of Drug Delivery Science and Technology (2018)
22. Production and Optimization of Valproic Acid Nanostructured Lipid Carriers by the Taguchi Design, Pharmaceutical Development and Technology (2010)
23. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
24. Plga-Peg-Ra-Based Polymeric Micelles for Tumor Targeted Delivery of Irinotecan, Pharmaceutical Development and Technology (2018)
25. Efavirenz Oral Delivery Via Lipid Nanocapsules: Formulation, Optimisation, and Ex-Vivo Gut Permeation Study, IET Nanobiotechnology (2018)
26. Feasibility of Haloperidol-Anchored Albumin Nanoparticles Loaded With Doxorubicin As Dry Powder Inhaler for Pulmonary Delivery, Pharmaceutical Development and Technology (2015)
27. Development and Evaluation of Sustained-Release Propranolol Wax Microspheres, Journal of Microencapsulation (2001)
28. Biotin-Encoded Pullulan-Retinoic Acid Engineered Nanomicelles: Preparation, Optimization and in Vitro Cytotoxicity Assessment in Mcf-7 Cells, Indian Journal of Pharmaceutical Sciences (2016)
29. Development and Optimization of Transferrin-Conjugated Nanostructured Lipid Carriers for Brain Delivery of Paclitaxel Using Box–Behnken Design, Pharmaceutical Development and Technology (2017)
30. Evaluation of Lipid Nanocarriers in the Form of Sln and Their Application in Drug Delivery, Nanochemistry Research (2023)
31. Design, Synthesis, and Comparison of Pla-Peg-Pla and Peg-Pla-Peg Copolymers for Curcumin Delivery to Cancer Cells, Polymers (2023)
32. Development and Optimization of Solid Lipid Nanoparticles of Amikacin by Central Composite Design, Journal of Liposome Research (2010)
33. Preparing Simvastatin Nanoparticles by a Combination of Ph-Sensitive and Timed-Release Approaches for the Potential Treatment of Ulcerative Colitis, Journal of Biomaterials Applications (2022)
34. Preparation and in Vitro Evaluation of Inhalation Powder Containing Fluconazole Nanoparticles for the Treatment of Fungal Lung Infections, Journal of Isfahan Medical School (2023)
35. Pharmacokinetics and in Vitro/In Vivo Antitumor Efficacy of Aptamer-Targeted Ecoflex® Nanoparticles for Docetaxel Delivery in Ovarian Cancer, International Journal of Nanomedicine (2018)
36. Peptide-Based Pegylated Polyurethane Nanoparticles for Paclitaxel Delivery in Hela Cancer Cells: The Art of the Architecture Design in Nanocarriers, Polymer Bulletin (2023)
37. Effects of Concentration, Temperature and Polymer Type on Drug Release From Montmorillonite-Donepezil Nanocomposites, Journal of Isfahan Medical School (2013)
38. Development and Validation of a New Robust Rp-Hplc Method for Simultaneous Quantitation of Insulin and Pramlintide in Non-Invasive and Smart Glucose-Responsive Microparticles, Research in Pharmaceutical Sciences (2022)
39. Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and in Vitro Characterization, Journal of Nanomaterials (2014)
40. Cytotoxic Effect of Pluronic F127-Poly (Methyl Vinyl Ether-Alt-Maleic Acid) Micelles Loaded With Doxorubicin on Mcf-7 Cells, Journal of Isfahan Medical School (2013)
41. Nanocrystalization of Pioglitazone by Precipitation Method, Drug Research (2018)
42. Biotin Decorated Sunitinib Loaded Nanostructured Lipid Carriers for Tumor Targeted Chemotherapy of Lung Cancer, Journal of Drug Delivery Science and Technology (2019)
43. Tissue Distribution and Systemic Toxicity Evaluation of Raloxifene Targeted Polymeric Micelles of Poly (Styrene-Maleic Acid)-Poly (Amide- Ether-Ester-Imide)-Poly (Ethylene Glycol) Loaded With Docetaxel in Breast Cancer Bearing Mice, Recent Patents on Anti-Cancer Drug Discovery (2019)
44. Factors Affecting the Production of Nanostructure Lipid Carriers of Valproic Acid, Journal of Biomedical Nanotechnology (2013)
45. The Effect of Formulation Variables on the Characteristics of Insulin-Loaded Poly(Lactic-Co-Glycolic Acid) Microspheres Prepared by a Single Phase Oil in Oil Solvent Evaporation Method, Colloids and Surfaces B: Biointerfaces (2009)
46. Co-Delivery of Carboplatin and Doxorubicin Using Zif-8 Coated Chitosan-Poly(N-Isopropyl Acrylamide) Nanoparticles Through a Dual Ph/Thermo Responsive Strategy to Breast Cancer Cells, International Journal of Biological Macromolecules (2024)
47. Co-Delivery of Paclitaxel and Α-Tocopherol Succinate by Novel Chitosan-Based Polymeric Micelles for Improving Micellar Stability and Efficacious Combination Therapy, Drug Development and Industrial Pharmacy (2015)
48. Co-Delivery of Arsenotungstate Polyoxometalate and Curcumin Using Bis-Imidazolium Poly Ionic Liquid Nanocomposites for Boosting Anticancer Effects Against Triple-Negative Breast Cancer Cells, Journal of Inorganic and Organometallic Polymers and Materials (2024)
49. Luteinizing Hormone-Releasing Hormone Targeted Poly(Methyl Vinyl Ether Maleic Acid) Nanoparticles for Doxorubicin Delivery to Mcf-7 Breast Cancer Cells, IET Nanobiotechnology (2016)
50. A Novel Mixed Polymeric Micelle for Co-Delivery of Paclitaxel and Retinoic Acid and Overcoming Multidrug Resistance: Synthesis, Characterization, Cytotoxicity, and Pharmacokinetic Evaluation, Drug Development and Industrial Pharmacy (2018)