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Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents Publisher Pubmed



Famouri F1 ; Shariat Z1 ; Hashemipour M1 ; Keikha M1 ; Kelishadi R1
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Authors Affiliations
  1. 1. Pediatrics Department, Child Growth and Development Research Center, Isfahan University of Medical Sciences, Hezarjerib Ave, Isfahan, Iran

Source: Journal of Pediatric Gastroenterology and Nutrition Published:2017


Abstract

Objectives: This study aims to evaluate the effects of some probiotics on sonographic and biochemical nonalcoholic fatty liver disease (NAFLD). Methods: This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 3×109 colony forming units [CFU]; Bifidobacterium lactis DSMZ 32269, 6×109 CFU; Bifidobacterium bifidum ATCC SD6576, 2×10-9CFU; Lactobacillus rhamnosus DSMZ 21690, 2×109 CFU) or placebo for 12 weeks. Results: After intervention, in the probiotic group the mean levels of alanine aminotransferase decreased from 32.8 (19.6) to 23.1 (9.9) U/L (P=0.02) and mean aspartate aminotransferase decreased from 32.2 (15.7) to 24.3 (7.7) U/L (P=0.02). Likewise the mean cholesterol, low-density lipoprotein-C, and triglycerides as well as waist circumference decreased in the intervention group, without significant change in weight, body mass index, and body mass index z score. After the trial, normal liver sonography was reported in 17 (53.1%) and 5 (16.5%) of patients in the intervention and placebo groups, respectively. Conclusions: The present findings suggest that a course of the abovementioned probiotic compound can be effective in improving pediatric NAFLD. Copyright © 2016 by European Society for Pediatric Gastroenterology.
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