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The Effects of Synbiotic Supplementation on Some Cardio-Metabolic Risk Factors in Overweight and Obese Children: A Randomized Triple-Masked Controlled Trial Publisher



Safavi M1, 2 ; Farajian S1, 2 ; Kelishadi R3 ; Mirlohi M1, 2, 4 ; Hashemipour M3
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan, Iran
  2. 2. Food Security Research Center, Faculty of Medicine and Child Growth, Development Research Center, Isfahan, Iran
  3. 3. Dept. of Pediatrics, Head, Child Growth, Faculty of Medicine and Child Growth, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Food Science and Technology Department, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Food Sciences and Nutrition Published:2013


Abstract

Recent studies have suggested some beneficial effects of probiotics on controlling excess weight in adults; such experience is limited in the pediatric age group. This study aimed to assess the anti-obesity and lipid-lowering effects of a synbiotic supplement among children and adolescents. We conducted a randomized triple-masked controlled trial among 70 participants aged 6-18 years with body mass index (BMI) equal or higher than 85th percentile. They were randomly assigned to two groups of equal number to receive synbiotic or placebo for 8 weeks. At the end of the trial, decrease in BMI Z-score, waist circumference, and waist-to-hip ratio were significantly higher in the synbiotic group than in the placebo group. Likewise, synbiotic group had significant decrease in serum triglycerides, total- and low density lipoprotein-cholesterol levels. The beneficial effects of a synbiotic supplement on controlling excess weight and some cardio-metabolic risk factors among children and adolescents can be considered in clinical practice. © 2013 Informa UK Ltd.
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Roya Kelishadi (57)
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