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The Effect of Pseudocatalase/Superoxide Dismutase in Treatment of Vitiligo: A Pilot Study



Fateminaeini F1 ; Vaezshooshtari A1 ; Ebrahimi B1 ; Nilforoushzadeh MA2 ; Molaei R1
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Authors Affiliations
  1. 1. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Isfahan Medical School Published:2014

Abstract

Background: Pseudocatalase/superoxide dismutase (PSD) is a topical gel considered having therapeutic effects in vitiligo. This study was designed to evaluate the efficacy of this combination in vitiligo. Methods: This was a pilot randomized, double-blind, placebo-controlled trial on 46 symmetrical vitiligo lesions of limbs in 23 patients referring to dermatology clinics in Isfahan, Iran, in 2010. Patients were received this formula or placebo gels for the right and left lesions. Lesion area and degree of pigmentation were assessed at baseline and 2, 4, and 6 months later. Findings: There were no significant changes in lesion area and perifollicular pigmentation in each group (P ={bullet operator}0.05). Conclusion: The results indicated no significant therapeutic effect for pseudocatalase/superoxide dismutase in vitiligo.
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