The Effects of a Novel Multicomponent Transition Metal Dichalcogenide on Nervous System Regeneration Publisher



Askari N¹ ; Askari MB² ; Shafieipour A³ ; Salek Esfahani B⁴ ; Hadizadeh M⁵ Show Affiliations
Source: Journal of Bionic Engineering Published:2022

Abstract

In regenerative medicine, a scaffold is needed to provide physical support for the growth of cells at the injury site. Carbon composites are also widely used in biomedicine. This research aimed to see if (MoWCu)S/rGO could be used in peripheral and central neural regeneration as a carbon-based nanomaterial. This material was created using a one-step hydrothermal process. We used Scanning Electron Microscopy with Energy Dispersive X-ray analysis (SEM–EDX), X-ray diffraction, and Field-Emission Scanning Electron Microscopy (FE-SEM) to describe it. The researchers used animal models of spinal cord injury and sciatic nerve injury to assess its effect as a scaffold of anti-inflammatory and electrical conductivity. The Basso Beattie Bresnahan locomotor rating scale and von Frey Filament were used to assess neuronal function after (MoWCu)S/rGO transplantation. In addition, the expression of p75 NTR and neurotrophic factors (BDNF, NT3, and NGF) mRNA in the experimental rats nerve was compared to the normal ones using Real-Time RT-qPCR. In the experimental groups, the use of (MoWCu)S/rGO resulted in a significant increase in neurotrophic factor gene expression, while p75 NTR was inversely decreased. In conclusion, we found that the nerve regeneration activity of the (MoWCu)S/rGO scaffold in rat models significantly increased motor function recovery in the treated groups. Furthermore, the current study explained the response of this composite to inflammatory neurodegenerative diseases. (MoWCu)S incorporation in graphene is thought to have excellent properties and may be used in regenerative medicine. © 2022, Jilin University.