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Effect of Sesame on Sperm Quality of Infertile Men



Khani B1 ; Bidgoli SR1 ; Moattar F2 ; Hassani H3
Authors
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Authors Affiliations
  1. 1. Department of Obstetrics and Gynecology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Department of Anatomy and Embryology, Kashan University of Medical Sciences, Kashan, Iran

Source: Journal of Research in Medical Sciences Published:2013

Abstract

Background: High level of semen reactive oxygen species is considered as an important factor in male infertility. Sesame has antioxidant properties, which could be effective on improvement of semen parameters. This study was designed to determine the effects of sesame on sperm quality. Materials and Methods: Twenty-five infertile men entered this clinical trial. They were treated with a 3-months course of taking 0.5mg/kg sesame. The pre intervention sperm analysis (sperm count, motile sperm percentage and normal morphology sperm percentage) was compared with post treatment sperm analysis. Based on the post intervention seamen analysis, patients were advised to undergo either IVF or ICSI to assess their fertility status. Results: There was significant improvement in the sperm count (10.56±5.25vs. 22.71±30.14 million per ml) and motility (15.32±13.58vs. 23.32±20.61 percent) after treatment with sesame (Pvalue: 0.04 and <0.0001 respectively), but there was no significant improvement in sperm morphology after the treatment (10.72±6.66vs. 13.20±11.14 percent, Pvalue: 0.10). Three patients (12%) underwent IUI, which resulted in 1 successful pregnancy. Two patients (8%) underwent ICSI, which was not successful; however2(8%) patients had spontaneous pregnancy. Fortunately, all pregnancies led to live birth. Except 1case of diarrhea, no other major side effect was reported. Conclusion: Sesame improved sperm count and motility, and can be prescribed as an effective and safe method for male factor infertility.
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