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Epi-Mirnas: Regulators of the Histone Modification Machinery in Human Cancer Publisher



Mortazavi D1 ; Sohrabi B2 ; Mosallaei M3 ; Narimansalehfam Z4 ; Bastami M5 ; Mansoori Y5 ; Daraei A6 ; Zununi Vahed S7 ; Navid S8 ; Saadatian Z9 ; Jamialahmadi T10 ; Teng Y11 ; Sahebkar A12, 13, 14, 15
Authors
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Authors Affiliations
  1. 1. Koc University, Research Center for Translational Medicine, Istanbul, Turkey
  2. 2. Department of Biology, Faculty of Sciences, Arak University, Arak, Iran
  3. 3. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Women's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Non Communicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  6. 6. Department of Medical Genetics, School of Medicine, Babol University of Medical Sciences, Babol, Iran
  7. 7. Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  8. 8. Department of Anatomy, Faculty of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Science, Gonabad, Iran
  9. 9. Department of Physiology, Faculty of Medicine, Infectious Diseases Research Center, Gonabad University of Medical Sciences, Gonabad, Iran
  10. 10. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, 30322, GA, United States
  12. 12. Applied Biomedical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  13. 13. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  14. 14. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  15. 15. Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Oncology Published:2022


Abstract

Cancer is a leading cause of death and disability worldwide. Epigenetic deregulation is one of the most critical mechanisms in carcinogenesis and can be classified into effects on DNA methylation and histone modification. MicroRNAs are small noncoding RNAs involved in fine-tuning their target genes after transcription. Various microRNAs control the expression of histone modifiers and are involved in a variety of cancers. Therefore, overexpression or downregulation of microRNAs can alter cell fate and cause malignancies. In this review, we discuss the role of microRNAs in regulating the histone modification machinery in various cancers, with a focus on the histone-modifying enzymes such as acetylases, deacetylases, methyltransferases, demethylases, kinases, phosphatases, desumoylases, ubiquitinases, and deubiquitinases. Understanding of microRNA-related aberrations underlying histone modifiers in pathogenesis of different cancers can help identify novel therapeutic targets or early detection approaches that allow better management of patients or monitoring of treatment response. © 2022 Deniz Mortazavi et al.
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