Epi-Mirnas: Regulators of the Histone Modification Machinery in Human Cancer Publisher



Mortazavi D¹ ; Sohrabi B² ; Mosallaei M³ ; Narimansalehfam Z⁴ ; Bastami M⁵ ; Mansoori Y⁵ ; Daraei A⁶ ; Zununi Vahed S⁷ ; Navid S⁸ ; Saadatian Z⁹ ; Jamialahmadi T¹⁰ ; Teng Y¹¹ ; Sahebkar A^{12, 13, 14, 15}
Source: Journal of Oncology Published:2022

Abstract

Cancer is a leading cause of death and disability worldwide. Epigenetic deregulation is one of the most critical mechanisms in carcinogenesis and can be classified into effects on DNA methylation and histone modification. MicroRNAs are small noncoding RNAs involved in fine-tuning their target genes after transcription. Various microRNAs control the expression of histone modifiers and are involved in a variety of cancers. Therefore, overexpression or downregulation of microRNAs can alter cell fate and cause malignancies. In this review, we discuss the role of microRNAs in regulating the histone modification machinery in various cancers, with a focus on the histone-modifying enzymes such as acetylases, deacetylases, methyltransferases, demethylases, kinases, phosphatases, desumoylases, ubiquitinases, and deubiquitinases. Understanding of microRNA-related aberrations underlying histone modifiers in pathogenesis of different cancers can help identify novel therapeutic targets or early detection approaches that allow better management of patients or monitoring of treatment response. © 2022 Deniz Mortazavi et al.