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Dysregulated Expression and Functions of Microrna-330 in Cancers: A Potential Therapeutic Target Publisher Pubmed



Jafarzadeh A1, 2 ; Paknahad MH3 ; Nemati M4, 5 ; Jafarzadeh S6 ; Mahjoubintehran M7 ; Rajabi A8, 9 ; Shojaie L10 ; Mirzaei H11
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  3. 3. Department of Cardiology, Chamran Cardiovascular Research Education Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  5. 5. Department of Haematology and Laboratory Sciences, School of Para-Medicine, Kerman University of Medical Sciences, Kerman, Iran
  6. 6. Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  7. 7. Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  8. 8. School of Medicine, Kashan University of Medical Sciences, Kashan, Iran
  9. 9. Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
  10. 10. Research center for Liver diseases, Keck school of medicine, Department of Medicine, University of Southern California, Los angeles, CA, United States
  11. 11. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

Source: Biomedicine and Pharmacotherapy Published:2022


Abstract

As small non-coding RNAs, MicroRNAs (miRNAs) bind to the 3′ untranslated region (3′-UTR) of mRNA targets to control gene transcription and translation. The gene of miR-330 has two miRNA products, including miR-330-3p and miR-330-5p, which exhibit anti-tumorigenesis and/or pro-tumorigenesis effects in many kinds of malignancies. In cancers, miR-330-3p and miR-330-5p aberrant expression can influence many malignancy-related processes such as cell proliferation, migration, invasion, apoptosis and epithelial-mesenchymal transition, as well as angiogenesis and responsiveness to treatment. In many cancer types (such as lung, prostate, gastric, breast, bladder, ovarian, colorectal, and pancreatic cancer, and osteosarcoma), miR-330-5p acts as an anti-tumor agent. These cancers have low levels of miR-330-5p that leads to the upregulation of the tumor promotor target genes leading to tumor progression. Here, overexpression of miR-330-5p using miRNA inducers can prevent tumor development. Dual roles of miR-330-5p have been also indicated in the thyroid, liver and cervical cancers. Moreover, miR-330-3p exhibits pro-tumorigenesis effects in lung cancer, pancreatic cancer, osteosarcoma, bladder cancer, and cervical cancer. Here, downregulation of miR-330-3p using miRNA inhibitors can prevent tumor development. Demonstrated in breast and liver cancers, miR-330-3p also has dual roles. Importantly, the activities of miR-330-3p and/or miR-330-5p are regulated by upstream regulators long non-coding RNAs (lncRNAs), including circular and linear lncRNAs. This review comprehensively explained miR-330-3p and miR-330-5p role in development of cancers, while highlighting their downstream target genes and upstream regulators as well as possible therapeutic strategies. © 2021 The Authors
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