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Case Report: Covid-19-Associated Mucormycosis Co-Infection With Lomentospora Prolificans: The First Case and Review on Multiple Fungal Co-Infections During Covid-19 Pandemic Publisher



Erami M1, 2 ; Mirhendi H3, 4 ; Momenheravi M2 ; Sharif A2 ; Hashemi Hezaveh SJ1 ; Matini AH5 ; Ahsaniarani AH6 ; Aboutalebian S3, 4
Authors
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Authors Affiliations
  1. 1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Infectious Diseases, School of Medicine, Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
  3. 3. Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Mycology Reference Laboratory, Research Core Facilities Laboratory, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Pathology and Histology, School of Medicine, Shahid Beheshti Hospital, Kashan University of Medical Sciences, Kashan, Iran
  6. 6. Department of Otorhinolaryngology, School of Medicine, Matini Hospital, Kashan University of Medical Sciences, Kashan, Iran

Source: Frontiers in Medicine Published:2023


Abstract

Along with the pandemic COVID-19 spreads, new clinical challenges have emerged in the health care settings, among which there is a high risk of secondary invasive fungal infections with significant mortality. Here, we report a case of invasive fungal rhino orbital sinusitis due to the simultaneous co-infection by Rhizopus oryzae and Lomentospora prolificans, both identified by sequencing, in a 70-year-old Afghanistanian female with COVID-19. The patient was subjected to surgical debridement as well as taking liposomal amphotericin B, voriconazole, and on discharge, her condition was good. As far as we know, this is the first case of co-infection of COVID-19-associated mucormycosis (CAM) and Lomentospora prolificans infection. Multiple fungal co-infections in COVID-19 patients are reviewed. Copyright © 2023 Erami, Mirhendi, Momen-Heravi, Sharif, Hashemi Hezaveh, Matini, Ahsaniarani and Aboutalebian.
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