Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Comparison of Quality of Life in Women Suffering From Cutaneous Leishmaniasis Treated With Topical and Systemic Glucantime Along With Psychiatric Consultation Compared With the Group Without Psychiatric Consultation



Nilforoushzadeh MA1 ; Roohafza HR2 ; Jaffary F3 ; Khatuni M4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Skin Disease and Leishmaniasis Research Center, Department of Pharmacology and Toxicology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Journal of Isfahan Medical School Published:2012

Abstract

Background: Cutaneous leishmaniasis (CL) is a parasitic disease which is endemic in Iran. Isfahan is one of the main centers of this disease. The aim of this study was to evaluate the effect of psychotherapy on quality of life (QOL) in women with CL treated with glucantime. Methods: In this study, 80 patients were randomly allocated to two groups, drug therapy and drug therapy plus psychotherapy. QOL was measured by dermatology life quality index (DLQI) and was compared at the beginning and the end of the intervention. Findings: The DLQI score before and after intervention in the group of drug therapy plus psychotherapy was 10.6 ± 5.7 and 7.7 ± 4.6, respectively, and their difference was statistically significant (P = 0.001). The score in drug therapy group before and after intervention was 10 ± 5.1 and 11 ± 5.1, respectively, which was not a significant difference. The mean difference of quality of life score before and after the treatment in the drug therapy plus psychotherapy group was 2.9 ± 5 and in the drug therapy group was 1.4 ± 4.2 (P < 0.001). Therefore, the quality of life was significantly higher in the patients treated with the combination of drug therapy and psychotherapy. Conclusion: Given the higher quality of life improvement by combination of psychotherapy and drug therapy in women with CL, psychiatric consultation is recommended. © 2012, Isfahan University of Medical Sciences(IUMS). All rights reserved.
Related Docs
View other Related Docs
1. Electrocardiographic Changes in Patients With Cutaneous Leishmaniasis Treated With Systemic Glucantime, Annals of the Academy of Medicine Singapore (2008)
2. A Comparison of the Effects of Topical Injection of Glucantime Plus Glycolic Acid 70% and Salicylic Acid 20% With Topical Injection of Glucantime Alone in the Treatment of Acute Cutaneous Leishmaniasis, Journal of Isfahan Medical School (2017)
3. The Efficacy of Intralesional Meglumine Antimoniate (Glucantime) Versus a Combination of Topical Trichloroacetic Acid 50% and Local Heat Therapy by Non-Ablative Radiofrequency on Cutaneous Leishmaniasis Lesions, Journal of Isfahan Medical School (2012)
4. Effect of Combination Therapy With Systemic Glucantime and Pentoxifylline in the Treatment of Cutaneous Leishmaniasis, International Journal of Dermatology (2006)
5. Comparison of Alexithymia, General Health and Coping Strategies Between Patients With Dermatologic Diseases and Control Group, Journal of Isfahan Medical School (2013)
6. Evaluation of Psychological Profile of Patients With Skin Lesions, Journal of Isfahan Medical School (2013)
7. Comparison of Healing Effects of Local Injection of Glucantime With or Without Trichloroacetic Acid 50% in Cutaneous Leshmaniasis, Journal of Isfahan Medical School (2009)
8. Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis, Journal of Isfahan Medical School (2014)
Experts (# of related papers)
View all Related Experts
Seyed Hossein Hejazi (15)
Ali Asilian (13)
Other Related Docs
9. Cutaneous Leishmaniasis Reinfection: Skin Disease and Leishmaniasis Research Center, Isfahan, Iran, Journal of Isfahan Medical School (2015)
10. Treatment of Recurrent Cutaneous Leishmaniasis, International Journal of Dermatology (1995)
11. Comparison of Three Different Therapies for Cutaneous Leishmaniasis and Identification of the Etiologic Isolates in Isfahan, Iran, Archives of Iranian Medicine (2020)
12. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Itraconazole in the Treatment of Cutaneous Leishmaniasis, Journal of the European Academy of Dermatology and Venereology (2005)
13. A Comparison Between the Effects of Glucantime, Topical Trichloroacetic Acid 50% Plus Glucantime, and Fractional Carbon Dioxide Laser Plus Glucantime on Cutaneous Leishmaniasis Lesions, Dermatology Research and Practice (2016)
14. Treatment of Cutaneous Leishmaniasis With Ketoconazole Cream, Journal of Dermatological Treatment (2003)
15. Evaluation of Leishmanin Skin Test and Its Relationship With the Clinical Form and Duration of Cutaneous Leishmaniasis, Dermatology Online Journal (2006)
16. Evaluation of Leishmanin Skin Test Reaction in Different Variants of Cutaneous Leishmaniasis, Indian Journal of Dermatology (2013)
17. The Skin Side Effects of Topical Glucantime in Patients With Cutaneous Leishmaniasis, Journal of Isfahan Medical School (2015)
18. A Comparison Between the Effects of Glucantime, Topical Trichloroacetic Acid 50% Plus Glucantime, and Fractional Laser Plus Glucantime on Cutaneous Leishmaniasis Lesions, Journal of Isfahan Medical School (2013)
19. Treatment of Acute Cutaneous Leishmaniasis With Intralesional Injection of Meglumine Antimoniate: Comparison of Conventional Technique With Mesotherapy Gun, International Journal of Dermatology (2010)
20. Comparative Study of the Efficacy of Combined Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime®) Vs. Cryotherapy and Intralesional Meglumine Antimoniate (Glucantime®) Alone for the Treatment of Cutaneous Leishmaniasis, International Journal of Dermatology (2004)
21. Treatment of Cutaneous Leishmaniasis With Aminosidine (Paromomycin) Ointment: Double-Blind, Randomized Trial in the Islamic Republic of Iran, Bulletin of the World Health Organization (2003)
22. A Comparative Study Between the Efficacy of Systemic Meglumine Antimoniate Therapy With Standard or Low Dose Plus Oral Omeprazole in the Treatment of Cutaneous Leishmaniasis, Journal of Vector Borne Diseases (2008)
23. The Effect of Intralesional Meglumine Antimoniate (Glucantime) Versus a Combination of Topical Trichloroacetic Acid 50% and Local Heat Therapy by Non-Ablative Radiofrequency on Cutaneous Leishmaniasis Lesions, Journal of Research in Medical Sciences (2012)
24. Evaluation of the 11-Year Trend of Cutaneous Leishmaniasis in Six Main Foci of the Disease in Isfahan Province During the Years 2008 to 2018, Journal of Isfahan Medical School (2022)
25. Efficacy of Integrated Pest Management in Controlling and Preventing Zoonotic Cutaneous Leishmaniasis in Isfahan Province, Iran, Journal of Isfahan Medical School (2012)
26. In Vitro Anti-Leishmanial Activity of Satureja Hortensis and Artemisia Dracunculus Extracts on Leishmania Major Promastigotes, Journal of Parasitic Diseases (2016)
27. Topical Effectiveness of Different Concentrations of Nanosilver Solution on Leishmania Major Lesions in Balb/C Mice, Journal of Vector Borne Diseases (2012)
28. Evaluation of Community Interventions in Changes in Incidence of Cutaneous Leishmaniasis in Isfahan Province From 2002 to 2018: An Interrupted Time Series Regression Analysis, Iranian Journal of Epidemiology (2021)
29. Treatment of Cutaneous Leishmaniasis: Cassia Fistula Fruit Gel-Intralesional Glucantime Vs. Placebo Gel- Intralesional Glucantime Combination, Tehran University Medical Journal (2010)
30. Serum Monocyte Chemotactic Protein-1 and Nitric Oxide in Cutaneous Leishmaniasis Patients Before and After Treatment With Glucantime, Journal of Isfahan Medical School (2012)
31. Epidemiological Aspects of Cutaneous Leishmaniasis in Iran, Archives of Clinical Infectious Diseases (2015)
32. Comparison of Intralesionally Injected Zinc Sulfate With Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis, Dermatology (2004)
33. Therapeutic Effect of Topical Tamoxifen in Murine Cutaneous Leishmaniasis Caused by Leishmania Major, Antimicrobial Agents and Chemotherapy (2024)
34. A Randomised, Double-Blind, Controlled Trial of a Killed L. Major Vaccine Plus Bcg Against Zoonotic Cutaneous Leishmaniasis in Iran, Vaccine (1999)
35. The Efficacy of 5% Trichloroacetic Acid Cream in the Treatment of Cutaneous Leishmaniasis Lesions, Journal of Dermatological Treatment (2012)
36. Application of Basnef Model in Students Training Regarding Cutaneous Leishmaniasis Prevention Behaviors: A School-Based Quasi Experimental Study, BMC Infectious Diseases (2021)
37. The Study of the Inhibitory Effects of Aqueous and Ethanolic Extracts of Ziziphora Tenuior L. on the Proliferation of Leishmania Major Amastigotes, Iranian Journal of Dermatology (2018)
38. Heat Therapy for Cutaneous Leishmaniasis: A Literature Review, Journal of Research in Medical Sciences (2021)
39. Effect of Adjunctive Topical Liposomal Azithromycin on Systemic Azithromycin on Old World Cutaneous Leishmaniasis: A Pilot Clinical Study, Iranian Journal of Pharmaceutical Research (2021)
40. Effect of Topical Honey Application Along With Intralesional Injection of Glucantime in the Treatment of Cutaneous Leishmaniasis, BMC Complementary and Alternative Medicine (2007)
41. Identification of Leishmania Isolates From Healing and Nonhealing Cutaneous Leishmaniasis Patients Using Internal Transcribed Spacer Region Pcr, Jundishapur Journal of Microbiology (2014)
42. Comparative Effect of Topical Trichloroacetic Acid and Intralesional Meglumine Antimoniate in the Treatment of Acute Cutaneous Leishmaniasis, International Journal of Pharmacology (2006)
43. Demographic and Clinical Characteristics of Children With Cutaneous Leishmaniasis in Isfahan Province, Iran, During 2011-2015, Journal of Isfahan Medical School (2017)
44. Anti-Leishmaniasis Effect of Staphylococcus Aureus Protein a on the Size of the Lesion and Parasitic Load, Advanced Biomedical Research (2023)
45. Isolation of Bacteria Causing Secondary Bacterial Infection in the Lesions of Cutaneous Leishmaniasis, Indian Journal of Dermatology (2008)
46. Clinical Picture of Cutaneous Leishmaniasis in Isfahan, Iran, International Journal of Dermatology (1994)
47. Preparation and Evaluation of Clinical Effects of Glucantime Gel Mask, Journal of Isfahan Medical School (2013)
48. Effect of Acupuncture Treatment on Level of Serum Interferon (Ifn)-Γ in Balb/C Model of Leishmania Major Infection, Journal of Isfahan Medical School (2013)
49. Efficacy of Adjunctive Topical Liposomal Clarithromycin on Systemic Glucantime in Old World Cutaneous Leishmaniasis: A Pilot Clinical Study, Frontiers in Pharmacology (2023)
50. Treatment of Glucantim™-Resistant Cutaneous Leishmaniasis Using Combination Therapy of Allopurinol and Trichloroacetic Acid (Tca) 50%; Report of Three Cases, Journal of Isfahan Medical School (2017)