Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway

Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway Publisher Pubmed

Martinelli M¹ ; Girardi A¹ ; Cura F¹ ; Nouri N² ; Pinto V³ ; Carinci F⁴ ; Morselli PG¹ ; Salehi M⁵ ; Scapoli L¹

Show Affiliations

1. Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Belmeloro, 8, Bologna, 40126, Italy
2. Medical Genetics Laboratory, Alzahra University Hospital, Isfahan University of Medical Sciences, Isfahan, 81745-319, Iran
3. Plastic Surgery Unit, Sant'Orsola Malpighi University Hospital, Via Massarenti, 9, Bologna, 40138, Italy
4. Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Luigi Borsari, 46, Ferrara, 44121, Italy
5. Department of Genetics and Molecular Biology, Medical School, Isfahan University of Medical Sciences, Isfahan, 81745-319, Iran

Source: Archives of Oral Biology Published:2016

Abstract

Objective Orofacial clefts (OFCs) are one of the most common birth defects in humans. They are the subject of a number of investigations aimed at elucidating the bases of their complex mode of inheritance involving both genetic and environmental factors. Genes belonging to the folate pathway have been among the most studied. The aim of the investigation was to replicate previous studies reporting evidence of association between polymorphisms of folate related genes and the occurrence of non-syndromic cleft lip with or without cleft palate (NSCL/P), using three independent samples of different ancestry: from Tibet, Bangladesh and Iran, respectively. Design Specifically, the polymorphisms rs1801133 of MTHFR, rs1801198 of TCN2, and rs4920037 of CBS, were tested. Results A decreased risk of NSCL/P was observed in patients presenting the C677T variant at MTHFR gene (relative risk for heterozygotes = 0.53; 95% confidence interval [C.I.] = 0.32-0.87). The investigated polymorphisms mapping at TCN2 and CBS genes did not provide any evidence of association. Conclusion Overall, these results indicate that NSCL/P risk factors differ among populations and confirm the importance of testing putative susceptibility variants in different genetic backgrounds. © 2015 Elsevier Ltd. All rights reserved.

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Style	Citing Format
MLA	Martinelli M, et al.. "Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway." Archives of Oral Biology, vol. 61, no. , 2016, pp. 79-82.
APA	Martinelli M, Girardi A, Cura F, Nouri N, Pinto V, Carinci F, Morselli PG, Salehi M, Scapoli L (2016). Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway. Archives of Oral Biology, 61(), 79-82.
Chicago	Martinelli M, Girardi A, Cura F, Nouri N, Pinto V, Carinci F, Morselli PG, Salehi M, Scapoli L. "Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway." Archives of Oral Biology 61, no. (2016): 79-82.
Harvard	Martinelli M et al. (2016) 'Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway', Archives of Oral Biology, 61(), pp. 79-82.
Vancouver	Martinelli M, Girardi A, Cura F, Nouri N, Pinto V, Carinci F, et al.. Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway. Archives of Oral Biology. 2016;61():79-82.
BibTex	@article{ author = {Martinelli M and Girardi A and Cura F and Nouri N and Pinto V and Carinci F and Morselli PG and Salehi M and Scapoli L}, title = {Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway}, journal = {Archives of Oral Biology}, volume = {61}, number = {}, pages = {79-82}, year = {2016} }
RIS	TY - JOUR AU - Martinelli M AU - Girardi A AU - Cura F AU - Nouri N AU - Pinto V AU - Carinci F AU - Morselli PG AU - Salehi M AU - Scapoli L TI - Non-Syndromic Cleft Lip With or Without Cleft Palate in Asian Populations: Association Analysis on Three Gene Polymorphisms of the Folate Pathway JO - Archives of Oral Biology VL - 61 IS - SP - 79 EP - 82 PY - 2016 ER -

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