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3-Dimensional Printing of Hydrogel-Based Nanocomposites: A Comprehensive Review on the Technology Description, Properties, and Applications Publisher



Soleymani Eil Bakhtiari S1 ; Bakhsheshirad HR1, 2 ; Karbasi S3 ; Razzaghi M1 ; Tavakoli M4 ; Ismail AF5 ; Sharif S2 ; Ramakrishna S6 ; Chen X7 ; Berto F8
Authors
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Authors Affiliations
  1. 1. Advanced Materials Research Center, Department of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
  2. 2. Faculty of Engineering, Universiti Teknologi Malaysia, Johor Bahru, 81310, Johor, Malaysia
  3. 3. Biomaterials and Tissue Engineering Department, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461, Iran
  4. 4. Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran
  5. 5. Advanced Membrane Technology Research Center (AMTEC), Universiti Teknologi Malaysia, Johor Bahru, 81310, Johor, Malaysia
  6. 6. Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore, 117576, Singapore
  7. 7. Division of Biomedical Engineering, College of Engineering, University of Saskatchewan, Saskatoon, S7N 5A9, SK, Canada
  8. 8. Department of Mechanical and Industrial Engineering, Norwegian University of Science and Technology, Trondheim, 7491, Norway

Source: Advanced Engineering Materials Published:2021


Abstract

Increasing demand for customized implants and tissue scaffolds requires advanced biomaterials and fabricating processes for fabricating three-dimensional (3D) structures that resemble the complexity of the extracellular matrix (ECM). Lately, biofabrication approaches such as cell-laden (soft) hydrogel 3D printing (3DP) have been of increasing interest in the development of 3D functional environments similar to natural tissues and organs. Hydrogels that resemble biological ECMs can provide mechanical support and signaling cues to cells to control their behavior. Although the capability of hydrogels to produce artificial ECMs can regulate cellular behavior, one of the major drawbacks of working with hydrogels is their inferior mechanical properties. Therefore, keeping and enhancing the mechanical integrity of fabricated scaffolds has become an essential matter for 3D hydrogel structures. Herein, 3D-printed hydrogel-based nanocomposites (NCs) are evaluated systematically in terms of introducing novel techniques for 3DP of hydrogel-based materials, properties, and biomedical applications. © 2021 The Authors. Advanced Engineering Materials published by Wiley-VCH GmbH
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