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Comparative Evaluation of Tacrolimus Versus Interferon Alpha-2B Eye Drops in the Treatment of Vernal Keratoconjunctivitis: A Randomized, Double-Masked Study Publisher Pubmed



Zanjani H1 ; Aminifard MN1 ; Ghafourian A2 ; Pourazizi M3, 4 ; Maleki A1 ; Arish M1 ; Shahrakipoor M5 ; Rohani MR1 ; Abrishami M2 ; Zare EK1 ; Jalali FB1
Authors
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Authors Affiliations
  1. 1. Department of Ophthalmology, Alzahra Eye Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
  2. 2. Eye Research Center, Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, 1336616351, Iran
  3. 3. Cancer Research Center, Semnan University of Medical Sciences, Semnan, Iran
  4. 4. Department of Ophthalmology, Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Department of Epidemiology and Biostatistics, Zahedan University of Medical Sciences, Zahedan, Iran

Source: Cornea Published:2017


Abstract

Purpose: Vernal keratoconjunctivitis (VKC) is a bilateral, chronic, external ocular inflammatory disorder that mainly affects patients in their first or second decade. This study was designed to compare tacrolimus and interferon alpha-2b (IFN alpha-2b) eye drops in the treatment of VKC. Methods: In this randomized, double-masked clinical trial, 40 consecutive patients with VKC were sent to a referral eye hospital in a tropical region southeast of Iran. Patients were randomly assigned to receive either 0.005% tacrolimus or IFN alpha-2b (1,000,000 units/cc). Chi-square and t tests were used for comparison of outcomes between both groups. Results: Mean 6 SD age was 11.1 6 5.2 years. Thirty-one patients (77.5%) were male. The mean duration of disease was 3.4 6 2.9 years. In this study, the signs and symptoms were significantly reduced in patients after treatment in both groups (P = 0.0001). In the tacrolimus group, all patients responded to treatment whereas only one subject in the IFN group failed to respond (P = 0.99). Side effects in both groups were mild and tolerable. Conclusions: This study indicated that both 0.005% tacrolimus and IFN alpha-2b are effective and appear to be safe in treatment of recalcitrant VKC. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved..
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