Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments

Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments

Pessaran Z¹ ; Sahebfosul F¹ ; Oreizi F¹ ; Ghavaminejad A¹ ; Kiani A¹ ; Siadat ZD¹

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1. Department of Immunology, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Allergy, Asthma and Immunology Published:2005

Abstract

Tuberculosis is a chronic mycobacterial infection. The main effector cells against mycobacterium tuberculosis are CD4+ T lymphocytes. Our objective in this research was to evaluate the quantity of T lymphocytes and their subpopulations before and after treatments with combination of 4 drugs (Rifampcin, Isoniaside, pyrasinamide, Ethambutal) for 2 months directly in sputum-positive tuberculosis patients. Twenty patients as cases and twenty healthy people were selected as controls. Flow cytometry was used for TCD3+, TCD4+ and TCD8+ lymphocytes by using monoclonal antibodies. Our results indicated that there was alteration in cell mediated immunity during tuberculosis showing itself as decrease in TCD3+ and TCD4+ lymphocytes and increase in TCD8+ lymphocytes. The changes in TCD3+ and TCD4+ but not in TCD8+ were reversible after 2 months of treatment.

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Style	Citing Format
MLA	Pessaran Z, et al.. "Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments." Iranian Journal of Allergy, Asthma and Immunology, vol. 4, no. 1, 2005, pp. 23-26.
APA	Pessaran Z, Sahebfosul F, Oreizi F, Ghavaminejad A, Kiani A, Siadat ZD (2005). Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments. Iranian Journal of Allergy, Asthma and Immunology, 4(1), 23-26.
Chicago	Pessaran Z, Sahebfosul F, Oreizi F, Ghavaminejad A, Kiani A, Siadat ZD. "Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments." Iranian Journal of Allergy, Asthma and Immunology 4, no. 1 (2005): 23-26.
Harvard	Pessaran Z et al. (2005) 'Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments', Iranian Journal of Allergy, Asthma and Immunology, 4(1), pp. 23-26.
Vancouver	Pessaran Z, Sahebfosul F, Oreizi F, Ghavaminejad A, Kiani A, Siadat ZD. Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments. Iranian Journal of Allergy, Asthma and Immunology. 2005;4(1):23-26.
BibTex	@article{ author = {Pessaran Z and Sahebfosul F and Oreizi F and Ghavaminejad A and Kiani A and Siadat ZD}, title = {Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments}, journal = {Iranian Journal of Allergy, Asthma and Immunology}, volume = {4}, number = {1}, pages = {23-26}, year = {2005} }
RIS	TY - JOUR AU - Pessaran Z AU - Sahebfosul F AU - Oreizi F AU - Ghavaminejad A AU - Kiani A AU - Siadat ZD TI - Immunophenotypic Characterization of Peripheral Blood T-Lymphocytes and Their Subpopulations in Tuberculosis Patients Before and After Treatments JO - Iranian Journal of Allergy, Asthma and Immunology VL - 4 IS - 1 SP - 23 EP - 26 PY - 2005 ER -

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