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Comparison of Omicron and Delta Variants of Sars-Cov-2: A Systematic Review of Current Evidence Publisher Pubmed



Seyedalinaghi S1 ; Afsahi AM2 ; Mirzapour P1 ; Afzalian A3 ; Shahidi R4 ; Dashti M5 ; Ghasemzadeh A5 ; Paranjkhoo P6 ; Parsaei Z7 ; Pashaei A8 ; Mohammadi P9 ; Najafi MS10 ; Mahrokhi S1 ; Matini P9 Show All Authors
Authors
  1. Seyedalinaghi S1
  2. Afsahi AM2
  3. Mirzapour P1
  4. Afzalian A3
  5. Shahidi R4
  6. Dashti M5
  7. Ghasemzadeh A5
  8. Paranjkhoo P6
  9. Parsaei Z7
  10. Pashaei A8
  11. Mohammadi P9
  12. Najafi MS10
  13. Mahrokhi S1
  14. Matini P9
  15. Moradi A9
  16. Karimi A9
  17. Afroughi S11
  18. Mehraeen E12
  19. Dadras O13
Show Affiliations
Authors Affiliations
  1. 1. Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Radiology, School of Medicine, University of California, San Diego (UCSD), CA, United States
  3. 3. School of medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  5. 5. Department of Radiology, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Turpanjian College of Health Sciences, American University of Armenia, Yerevan, 0019, Armenia
  7. 7. Health Information Technology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  8. 8. School of Nursing, University of British Columbia, Vancouver, BC, Canada
  9. 9. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  10. 10. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Department of Biostatistics and Epidemiology, School of Health and Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, 7591875114, Iran
  12. 12. Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran
  13. 13. Department of Global Public Health and Primary Care, University of Bergen, Bergen, 5007, Norway

Source: Infectious Disorders - Drug Targets Published:2024


Abstract

Introduction: Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) caused the outbreak of coronavirus disease 2019 (COVID-19) in late 2019 in Wuhan, China. In early 2020, the disease spread rapidly around the world. Since the pandemic, SARS-CoV-2 has evolved dramatically into a wide variety of variants endowed with devastating properties. As of March 6, 2022, five SARS-CoV-2 variants of concern, including Alpha, Beta, Gamma, Delta, and Omicron strains have been identified. Due to the crucial importance of understanding the differences between the Omicron and Delta variants, this systematic review was conducted. Methods: This systematic review investigated new variants of Omicron SARS-CoV-2 based on current studies. Online databases were searched for English articles as of January 03, 2023. Selection of publications was a two-step process of title/abstract and full-text assessment against eligibility criteria. The relevant data from the included articles were systematically collected and organized in a designed table for analysis. To ensure the quality of the review, the PRISMA checklist and Newcastle-Ottawa Scale (NOS) of quality assessment were utilized. Results: The data extracted from 58 articles were analyzed, including 10003 pieces of evidence. Lower risk of hospitalization, ICU admission, and mortality after vaccination were reported in the Omicron variant compared to the Delta variant. Additionally, the Delta variant led to more severe clinical symptoms in comparison to the Omicron variant. Conclusion: The Omicron variant of SARS-CoV-2 results in less severe disease outcomes as compared to Delta. Nevertheless, it remains crucial to maintain ongoing monitoring, implement containment measures, and adapt vaccination protocols to effectively address the evolving variants. © 2024 Bentham Science.
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