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Corticosteroid Therapy for 2019 Novel Coronavirus: Lessons From Sars and Mers Publisher



Fathi M1 ; Vakili K1 ; Hajibeygi R2 ; Deravi N1 ; Tavasol A1 ; Yaghoobpoor S1 ; Ahsan E1 ; Mokhtari M3 ; Fazel T4 ; Kassaian N5
Authors
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Authors Affiliations
  1. 1. Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cardiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  3. 3. Student Research Committee, Faculty of Dentistry, Tehran Medical sciences, Islamic Azad University, Tehran, Iran
  4. 4. Student Research Committee, School of International Campus, Guilan University of Medical Sciences, Rasht, Iran
  5. 5. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Avicenna Journal of Clinical Microbiology and Infection Published:2021


Abstract

For the last three decades, the world population has experienced new epidemics of coronaviruses. The world is currently witnessing the novel coronavirus disease (COVID-19) epidemic, which is a disease that comes from a novel coronavirus called Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The available genetic and clinical proofs suggest a similar route to those of Middle East respiratory syndrome (MERS) and SARS. The clinical manifestations of infections caused by coronaviruses including SARS, MERS, and COVID-19 are pneumonia, bronchitis, or other serious respiratory infections. Various transmission ways (e.g., nosocomial transmission) and transmission through moderately symptomatic or non-symptomatic infected individuals have caused great concerns. Although no certain treatment has so far been developed for this disease, and prevention is the main applied strategy for these viruses, some medications can be used to help with this disease. Corticosteroids can be mentioned as an example of these medications. This article specifically reviewed the evidence regarding the effectiveness of the corticosteroid therapy for the coronavirus family (i.e., SARS, MERS, and COVID-19) and showed that there are insufficient data to recommend corticosteroid therapy for patients suffering from COVID-19. © 2021 The Author(s).
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