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An Updated Review of the Association of Host Genetic Factors With Susceptibility and Resistance to Covid-19 Publisher Pubmed



Mohammadpour S1 ; Torshizi Esfahani A2 ; Halaji M3 ; Lak M4 ; Ranjbar R5
Authors
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Authors Affiliations
  1. 1. Department of Biology, Islamic Azad University, Marvdasht Branch, Marvdasht, Iran
  2. 2. Department of Biology, Faculty of Biological Sciences, Islamic Azad University, North Tehran Branch, Tehran, Iran
  3. 3. Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Microbiology, Faculty of Advanced Science and Technology, Islamic Azad University Tehran Medical Sciences, Tehran, Iran
  5. 5. Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran

Source: Journal of Cellular Physiology Published:2021


Abstract

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human populations sparked a global pandemic of the coronavirus disease 2019 (COVID-19). According to preliminary data, about 14% of cases are considered severe and 5% of cases result in critical illness and, reported case fatality rates vary from 1% to more than 7%. However, the symptoms of the disease and the clinical outcome are very different in infected people. In view of these differences, it is clearly apparent that to gain insight into the biology of the SARS-CoV-2, it is important to study not just the infectious particle in itself but also to investigate the virus-host cell interactions that occur during infection. This review seeks to consider the various aspects of genetic factors in determining the susceptibility and host resistance to SARS-CoV-2 throughout the recently published literature. © 2020 Wiley Periodicals LLC
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