Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]

Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis] Publisher Pubmed

Malek M¹ ; Sarkaki A^{2, 4} ; Zahediasl S³ ; Rajaei Z¹ ; Farbood Y^{2, 4}

Show Affiliations

1. Isfahan University of Medical Sciences, School of Medicine, Department of Physiology, Isfahan, Iran
2. Ahvaz Jundishapur University of Medical Sciences, Physiology Research Center, Ahvaz, Iran
3. Shaheed Beheshti University of Medical Sciences, Research Institute for Endocrine Sciences, Endocrine Research Center, Tehran, Iran
4. Ahvaz Jundishapur University of Medical Sciences, School of Medicine, Department of Physiology, Ahvaz, Iran

Source: Arquivos de Neuro-Psiquiatria Published:2017

Abstract

In this study, we proposed that administration of hippocampal growth hormone in ageing animals with growth hormone deficiency can compensate long-term potentiation and synaptic plasticity in nucleus basalis magnocellularis (NBM)-lesioned rats. Aged male Wistar rats were randomly divided into six groups (seven in each) of sham-operated healthy rats (Cont); NBM-lesioned rats (L); NBM-lesioned rats and intrahippocampal injection of growth hormone vehicle (L + Veh); NBM-lesioned and intrahippocampal injection of growth hormone (10, 20 and 40 μg.2 μl-1) (L + GH). In vivo electrophysiological recording techniques were used to characterize maintenance of long-term potentiation at distinct times (1, 2, 3, 24 and 48 hours) after high-frequency stimulation. The population spike was enhanced significantly for about 48 hours following tetanic stimulation in rats treated with a dose-dependent growth hormone compared to the vehicle group (p < 0.05), possibly through neuronal plasticity and neurogenesis in affected areas. © 2017, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.

Related Docs

View other Related Docs

1. The Effects of Nbm- Lesion on Synaptic Plasticity in Rats, Brain Research (2017)

2. Novel Effects of Rosa Damascena Extract on Memory and Neurogenesis in a Rat Model of Alzheimer's Disease, Journal of Neuroscience Research (2014)

3. Effect of Exercise, Exercise Withdrawal, and Continued Regular Exercise on Excitability and Long-Term Potentiation in the Dentate Gyrus of Hippocampus, Brain Research (2016)

4. Effect of Chronic Stress on Short and Long-Term Plasticity in Dentate Gyrus; Study of Recovery and Adaptation, Neuroscience (2014)

5. Effects of Amitriptyline and Fluoxetine on Synaptic Plasticity and Tnf-Α Level at Hippocampus of Streptozotocin-Induced Diabetic Rats, Physiology and Pharmacology (2017)

6. Neuroprotective and Long Term Potentiation Improving Effects of Vitamin E in Juvenile Hypothyroid Rats, International Journal for Vitamin and Nutrition Research (2020)

7. Quercetin Promotes Learning and Memory Performance Concomitantly With Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Adult Rat Dentate Gyrus, International Journal of Developmental Neuroscience (2019)

8. The Impacts of Diabetes in Pregnancy on Hippocampal Synaptogenesis in Rat Neonates, Neuroscience (2016)

Experts (# of related papers)

View all Related Experts

Parham Reisi (4)

Hojatallah Alaei (4)

Style	Citing Format
MLA	Malek M, et al.. "Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]." Arquivos de Neuro-Psiquiatria, vol. 75, no. 7, 2017, pp. 477-483.
APA	Malek M, Sarkaki A, Zahediasl S, Rajaei Z, Farbood Y (2017). Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]. Arquivos de Neuro-Psiquiatria, 75(7), 477-483.
Chicago	Malek M, Sarkaki A, Zahediasl S, Rajaei Z, Farbood Y. "Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]." Arquivos de Neuro-Psiquiatria 75, no. 7 (2017): 477-483.
Harvard	Malek M et al. (2017) 'Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]', Arquivos de Neuro-Psiquiatria, 75(7), pp. 477-483.
Vancouver	Malek M, Sarkaki A, Zahediasl S, Rajaei Z, Farbood Y. Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]. Arquivos de Neuro-Psiquiatria. 2017;75(7):477-483.
BibTex	@article{ author = {Malek M and Sarkaki A and Zahediasl S and Rajaei Z and Farbood Y}, title = {Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]}, journal = {Arquivos de Neuro-Psiquiatria}, volume = {75}, number = {7}, pages = {477-483}, year = {2017} }
RIS	TY - JOUR AU - Malek M AU - Sarkaki A AU - Zahediasl S AU - Rajaei Z AU - Farbood Y TI - Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis] JO - Arquivos de Neuro-Psiquiatria VL - 75 IS - 7 SP - 477 EP - 483 PY - 2017 ER -

Style

Citing Format

MLA

Malek M, et al.. "Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]." Arquivos de Neuro-Psiquiatria, vol. 75, no. 7, 2017, pp. 477-483.

APA

Malek M, Sarkaki A, Zahediasl S, Rajaei Z, Farbood Y (2017). Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]. Arquivos de Neuro-Psiquiatria, 75(7), 477-483.

Chicago

Malek M, Sarkaki A, Zahediasl S, Rajaei Z, Farbood Y. "Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]." Arquivos de Neuro-Psiquiatria 75, no. 7 (2017): 477-483.

Harvard

Malek M et al. (2017) 'Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]', Arquivos de Neuro-Psiquiatria, 75(7), pp. 477-483.

Vancouver

Malek M, Sarkaki A, Zahediasl S, Rajaei Z, Farbood Y. Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]. Arquivos de Neuro-Psiquiatria. 2017;75(7):477-483.

BibTex

@article{ author = {Malek M and Sarkaki A and Zahediasl S and Rajaei Z and Farbood Y}, title = {Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]}, journal = {Arquivos de Neuro-Psiquiatria}, volume = {75}, number = {7}, pages = {477-483}, year = {2017} }

RIS

TY - JOUR
AU - Malek M
AU - Sarkaki A
AU - Zahediasl S
AU - Rajaei Z
AU - Farbood Y
TI - Effect of Intra-Hippocampal Injection of Human Recombinant Growth Hormone on Synaptic Plasticity in the Nucleus Basalis Magnocellularis-Lesioned Aged Rats; [Efeito Da Injecao Intrahipocampal De Hormonio Do Crescimento Humano Recombinante Sobre a Plasticidade Sinaptica Em Ratos Envelhecidos Lesados Do Nucleo Basalis Magnocellularis]
JO - Arquivos de Neuro-Psiquiatria
VL - 75
IS - 7
SP - 477
EP - 483
PY - 2017
ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract