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Novel Effects of Rosa Damascena Extract on Memory and Neurogenesis in a Rat Model of Alzheimer's Disease Publisher Pubmed



Esfandiary E1 ; Karimipour M1 ; Mardani M1 ; Alaei H2 ; Ghannadian M3 ; Kazemi M4 ; Mohammadnejad D5 ; Hosseini N2 ; Esmaeili A6
Authors
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Authors Affiliations
  1. 1. Department of Anatomical Sciences and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran
  3. 3. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  4. 4. Department of Genetic, Isfahan University of Medical Sciences, Isfahan, Iran
  5. 5. Electron Microscopy Research center, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Cells, Molecular Biology and Biochemistry Division, Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran

Source: Journal of Neuroscience Research Published:2014


Abstract

The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage in the early stages of AD. Emerging evidence suggests that loss of neurons and synapses are correlated with dementia in this devastating disease. Therefore, neurogenesis and synaptogenesis in adulthood could serve as a preventive as well as a therapeutic target for AD. This study investigated the effect of Rosa damascena extract on neurogenesis and synaptogenesis in an animal model of AD. Molecular, cellular, and behavioral experiments revealed that this treatment could induce neurogenesis and synaptic plasticity and improve memory in AD. Our study suggests that R. damascena is a promising treatment for mild memory impairments and AD. © 2013 Wiley Periodicals, Inc.
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