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Quercetin Promotes Learning and Memory Performance Concomitantly With Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Adult Rat Dentate Gyrus Publisher Pubmed



Karimipour M1, 2, 3, 4 ; Rahbarghazi R2, 3 ; Tayefi H1 ; Shimia M5 ; Ghanadian M6 ; Mahmoudi J4 ; Bagheri HS3
Authors
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Authors Affiliations
  1. 1. Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Neuroscience Research Center, Advanced Biomedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  6. 6. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Source: International Journal of Developmental Neuroscience Published:2019


Abstract

The decline in neurogenesis is a very critical problem in Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin. Herein, we investigated the neurogenesis potential of quercetin in a rat model of Alzheimer's disease induced by amyloid-beta injection. Rats were randomly divided into Control, Alzheimer + Saline and Alzheimer + Quercetin groups. Following the administration of Amyloid-beta, rats in the Alzheimer + Quercetin group received 40 mg/kg/day quercetin orally for one month. Our data demonstrated amyloid-β injection could impair learning and memory processing in rats indicated by passive avoidance test evaluation. We noted that one-month quercetin treatment alleviated the detrimental effects of amyloid-β on spatial learning and memory parameters using Morris water maze analysis. Quercetin was found to increase the number of proliferating neural stem/progenitor cells. Notably, quercetin increased the number of DCX-expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus. We further observed that the quercetin improved the number of BrdU/NeuN positive cells contributed to enhanced adult neurogenesis. Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis. These data suggest that quercetin can play a valuable role in alleviating Alzheimer's disease symptoms by enhancing adult neurogenesis mechanism. © 2019
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