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Quercetin Promotes Learning and Memory Performance Concomitantly With Neural Stem/Progenitor Cell Proliferation and Neurogenesis in the Adult Rat Dentate Gyrus Publisher Pubmed

Summary: A study found quercetin boosts brain cell growth in Alzheimer’s model, improving memory. #Alzheimers #BrainHealth

Karimipour M1, 2, 3, 4 ; Rahbarghazi R2, 3 ; Tayefi H1 ; Shimia M5 ; Ghanadian M6 ; Mahmoudi J4 ; Bagheri HS3
Authors

Source: International Journal of Developmental Neuroscience Published:2019


Abstract

The decline in neurogenesis is a very critical problem in Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin. Herein, we investigated the neurogenesis potential of quercetin in a rat model of Alzheimer's disease induced by amyloid-beta injection. Rats were randomly divided into Control, Alzheimer + Saline and Alzheimer + Quercetin groups. Following the administration of Amyloid-beta, rats in the Alzheimer + Quercetin group received 40 mg/kg/day quercetin orally for one month. Our data demonstrated amyloid-β injection could impair learning and memory processing in rats indicated by passive avoidance test evaluation. We noted that one-month quercetin treatment alleviated the detrimental effects of amyloid-β on spatial learning and memory parameters using Morris water maze analysis. Quercetin was found to increase the number of proliferating neural stem/progenitor cells. Notably, quercetin increased the number of DCX-expressing cells, indicating the active dynamic growth of neural progenitor cells in the dentate gyrus of the hippocampus. We further observed that the quercetin improved the number of BrdU/NeuN positive cells contributed to enhanced adult neurogenesis. Based on our results, quercetin had the potential to promote the expression of BDNF, NGF, CREB, and EGR-1 genes involved in regulating neurogenesis. These data suggest that quercetin can play a valuable role in alleviating Alzheimer's disease symptoms by enhancing adult neurogenesis mechanism. © 2019
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