Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Catheter-Associated Blood Stream Infections Due to Candida Pararugosa in a Patient With Acute Myeloid Leukemia: A Case Report Publisher Pubmed



Nasri E1 ; Vaezi A2 ; Shelerangkon M1 ; Rizi MH1 ; Ghafel S1 ; Abbasi K3 ; Badali H4 ; Fakhim H1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
  2. 2. Department of Medical Laboratory Science, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran
  4. 4. Department of Molecular Microbiology & Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX, United States

Source: Brazilian Journal of Microbiology Published:2023


Abstract

Infections caused by uncommon Candida species have dramatically increased in recent decades, mostly among hematological malignancies. This report aims to present a case of Candida pararugosa bloodstream infection, review previous cases with C. pararugosa infections, and provide a concise review of the clinical background, risk factors, and brief the management of infections. A 3-year-old boy with a history of acute myeloid leukemia was hospitalized in Omid Hospital, Isfahan, Iran. Two consecutive blood cultures were taken from the peripheral vein and port catheter; after that, empirically meropenem was administered. Candida pararugosa were isolated from blood-based on conventional and molecular assays. Furthermore, the antifungal susceptibility profiles of the isolate were determined, which exhibited resistance to fluconazole (8 μg/mL). Antifungal therapy with caspofungin and removing the patient’s port led to a significant clinical improvement of the patient’s conditions. So far, in the literature review, 10 cases of clinical C. pararugosa isolates were found, of which 5 patients had bloodstream infections. Most patients with C. pararugosa infection presented with specific underlying conditions, such as malignancy, sarcoma, surgery, and adult acute myeloid leukemia. Patients with indwelling catheters run a high risk of acquiring C. pararugosa bloodstream infection. Therefore, special consideration should be given to opportunistic fungal infections in immunocompromised individuals using catheters. © 2023, The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.
Related Docs
View other Related Docs
1. Overview on the Infections Related to Rare Candida Species, Pathogens (2022)
2. Invasive Fungal Infection in Febrile Patients With Hematologic Malignancies Undergoing Chemotherapy in Iran, Endocrine, Metabolic and Immune Disorders - Drug Targets (2019)
3. Antifungal Susceptibility Analysis of Clinical Isolates of Candida Parapsilosis in Iran, Iranian Journal of Public Health (2016)
4. Epidemiology, Species Distribution, Antifungal Susceptibility, and Outcome of Candidemia in Intensive Care Units in Isfahan, Iran, Current Medical Mycology (2022)
5. In Vitro Activity of Juglone (5-Hydroxy-1,4-Naphthoquinone) Against Both Fluconazole-Resistant and Susceptible Candida Isolates; [Actividad in Vitro De Juglona (5-Hidroxi-1,4-Naftoquinona) Contra Aislamientos De Candida Resistentes Y Sensibles a Fluconazol], Revista Iberoamericana de Micologia (2022)
6. Species Distribution and Antifungal Susceptibility Profile of Candida Isolates From Blood and Other Normally Sterile Foci From Pediatric Icu Patients in Tehran, Iran, Medical Mycology (2020)
7. Cross-Sectional Study of Candidemia From Isfahan, Iran: Etiologic Agents, Predisposing Factors, and Antifungal Susceptibility Testing, Journal of Research in Medical Sciences (2021)
8. In-Vivo Efficiency of the Novel Azole Compounds (Attaf-1 and Attaf-2) Against Systemic Candidiasis in a Murine Model, Journal of Medical Mycology (2023)
Experts (# of related papers)
View all Related Experts
Rasoul Mohammadi (31)
Seyed Hossein Mirhendi Esfahani (26)
Other Related Docs
9. Microbial Epidemiology of Candidaemia in Neonatal and Paediatric Intensive Care Units at the Children's Medical Center, Tehran, Mycoses (2018)
10. Candida Africana Vulvovaginitis: Prevalence and Geographical Distribution, Journal de Mycologie Medicale (2020)
11. Epidemiologic and Antifungal Susceptibility Profile of Candiduria Among Patients Hospitalized in the Nephrology and Intensive Care Unit Wards, Tehran, Iran, Jundishapur Journal of Microbiology (2022)
12. Epidemiology and Antifungal Susceptibility of Candida Species Isolated From 10 Tertiary Care Hospitals in Iran, Microbiology Spectrum (2022)
13. In Vitro Activities of Six Antifungal Drugs Against Candida Glabrata Isolates: An Emerging Pathogen, Jundishapur Journal of Microbiology (2016)
14. Candidemia in Children Caused by Uncommon Species of Candida, Archives of Pediatric Infectious Diseases (2018)
15. Species Distribution and Susceptibility Profiles of Oral Candidiasis in Hematological Malignancy and Solid Tumor Patients, Brazilian Journal of Microbiology (2023)
16. Frequency of Uncommon Clinical Yeast Species Confirmed by Its-Sequencing, Archives of Clinical Infectious Diseases (2019)
17. Candida Urinary Tract Infection Among Icu Patients in Isfahan, Iran, Archives of Clinical Infectious Diseases (2019)
18. South Asian (Clade I) Candida Auris Meningitis in a Paediatric Patient in Iran With a Review of the Literature, Mycoses (2022)
19. Antifungal Activity of Anethum Graveolens Extract and Atrovastatin Against Candida Species Compared to Fluconazole, Journal of Isfahan Medical School (2015)
20. Frequency of Candida Species Isolated From Patients in Children’S Medical Center, Tehran, Iran, Archives of Pediatric Infectious Diseases (2018)
21. Antifungal Susceptibility Testing of Candida Species Isolated From the Immunocompromised Patients Admitted to Ten University Hospitals in Iran: Comparison of Colonizing and Infecting Isolates, BMC Infectious Diseases (2017)
22. A 3-Year Study of Candida Infections Among Patients With Malignancy: Etiologic Agents and Antifungal Susceptibility Profile, Frontiers in Cellular and Infection Microbiology (2023)
23. In Vitro Antifungal Susceptibility Pattern of Candida Species Isolated From Gastroesophageal Candidiasis, Gastroenterology and Hepatology from Bed to Bench (2021)
24. Multicenter Identification and Antifungal Susceptibility Patterns of Candida Species Isolated From Clinical Samples, Jundishapur Journal of Microbiology (2017)
25. Candida Palmioleophila Candidemia and Bacterial Co-Infection in a 3-Month-Old Infant With Biliary Atresia, Frontiers in Cellular and Infection Microbiology (2023)
26. Caspofungin-Non-Susceptible Candida Orthopsilosis Isolated From Onychomycosis in Iran, Iranian Journal of Public Health (2017)
27. The Frequency of Oral Candidiasis in Children and Adolescents With Leukemia in Isfahan Province, Iran, Journal of Isfahan Medical School (2017)
28. Characterization of Beta-Tubulin Dna Sequences Within Candida Parapsilosis Complex, Current Medical Mycology (2018)
29. An Alarming Rise of Non-Albicans Candida Species and Uncommon Yeasts in the Clinical Samples; a Combination of Various Molecular Techniques for Identification of Etiologic Agents, BMC Research Notes (2019)
30. The Evaluation of the Overexpression of the Erg-11, Mdr-1, Cdr-1, and Cdr-2 Genes in Fluconazole-Resistant Candida Albicans Isolated From Ahvazian Cancer Patients With Oral Candidiasis, Journal of Clinical Laboratory Analysis (2022)
31. Low Level of Antifungal Resistance in Iranian Isolates of Candida Glabrata Recovered From Blood Samples in a Multicenter Study From 2015 to 2018 and Potential Prognostic Values of Genotyping and Sequencing of Pdr1, Antimicrobial Agents and Chemotherapy (2019)
32. Amino Acid Substitutions in Erg11p of Azole-Resistant Candida Glabrata: Possible Effective Substitutions and Homology Modelling, Journal of Global Antimicrobial Resistance (2016)
33. Prevalence, Molecular Identification, and Genotyping of Candida Species Recovered From Oral Cavity Among Patients With Diabetes Mellitus From Tehran, Iran, Advanced Biomedical Research (2022)
34. Identification of Candida Species Isolated From Candiduria Patients Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism in Isfahan, Iran, Journal of Isfahan Medical School (2016)
35. The Matching Rate of the Frequency of the Isolated Candida Species Calculated by Morphological and Molecular Methods in Patients With Vaginitis, Journal of Isfahan Medical School (2017)
36. Immunomodulatory Drug Fingolimod (Fty720) Restricts the Growth of Opportunistic Yeast Candida Albicans in Vitro and in a Mouse Candidiasis Model, PLoS ONE (2022)
37. Utilization of Size Polymorphism in Its1 and Its2 Regions for Identification of Pathogenic Yeast Species, Journal of Medical Microbiology (2017)
38. Functional Analysis of Two Stat1 Gain-Of-Function Mutations in Two Iranian Families With Autosomal Dominant Chronic Mucocutaneous Candidiasis, Medical Mycology (2021)
39. Rapid Detection of Candida Species in Bronchoalveolar Lavage Fluid From Patients With Pulmonary Symptoms, Brazilian Journal of Microbiology (2016)
40. Evaluation of Rapid Diagnosis of Candidemia by Agglutination Test Using Gold Nanoparticles, Journal of Isfahan Medical School (2022)
41. Molecular Characterization of Candida Dubliniensis and Candida Albicans in the Oral Cavity of Drug Abusers Using Duplex Polymerase Chain Reaction, Current Medical Mycology (2018)
42. The First Case of Wickerhamomyces Anomalus Fungemia in Iran in an Immuneodeficient Child, a Review on the Literature, Journal of Medical Mycology (2023)
43. Methods for Identification of Candida Auris, the Yeast of Global Public Health Concern: A Review, Journal de Mycologie Medicale (2019)
44. The Frequency of Candiduria in Hospitalized Patients at Nephrology Department, Labbafinejad Hospital, Tehran, Iran, Journal of Isfahan Medical School (2017)
45. Regulation of Erg3, Erg6, and Erg11 Genes in Antifungal-Resistant Isolates of Candida Parapsilosis, Iranian Biomedical Journal (2017)
46. Medication-Use Evaluation of Caspofungin in Intensive Care Units of Alzahra Hospital, Isfahan, Iran, in Year 2015, Journal of Isfahan Medical School (2018)
47. Non-Invasive Methods to Diagnose Fungal Infections in Pediatric Patients With Hematologic Disorders, Jundishapur Journal of Microbiology (2016)
48. Identification of Candida Species and Antifungal Susceptibility in Cancer Patients With Oral Lesions in Ahvaz, Southern West of Iran, Advanced Biomedical Research (2020)
49. Yeast Species in the Respiratory Samples of Covid-19 Patients; Molecular Tracking of Candida Auris, Frontiers in Cellular and Infection Microbiology (2024)
50. Molecular Identification of Candida Species Isolated From Gastrooesophageal Candidiasis in Tehran, Iran, Gastroenterology and Hepatology from Bed to Bench (2015)